左旋门冬氨酸鸟苷酸联用复方甘草酸苷治疗肝硬化肝性脑病的探讨

尹合坤; 李启祥; 罗丹

左旋门冬氨酸鸟苷酸联用复方甘草酸苷治疗肝硬化肝性脑病的探讨

详细信息

中图分类号: R575.2;R747.9
计量
- 文章访问数: 2492
- HTML全文浏览量: 36
- PDF下载量: 800
- 被引次数: 0
出版历程
- 出版日期: 2007-04-20

The clinical study of L-ornithine-L-aspartate combined with SNMC for hepatic encephalopathy of liver cirrhosis

摘要

摘要: 探讨左旋门冬氨酸鸟苷酸（雅博司）联合复方甘草酸苷（美能）治疗肝硬化肝性脑病的疗效。80例肝硬化肝性脑病患者随机分为雅博司+美能治疗组（A组）和谷氨酸钠+美能治疗组（B组）疗程皆为7天。治疗后A组中24小时清醒34例,72小时清醒36例,B组24小时清醒20例,P<0.01,72小时清醒30例,P>0.05;A组血氨治疗前后分别为（76.25±26.5）umol/L vs（36.28±11.51）umol/L,B组为（71.58±16.99）umol/L vs（49.8±16.46）umol/L;P<0.05,A组血ALT治疗前后分别为（92.23±41.23）U/L vs（32.8±11.74）U/L;血清胆红素则分别为（40.05±15.12）umol/L vs（20.95±11.27）umol/L,P<0.001;B组血ALT治疗前后分别为（87.93±40.72）U/L vs（34.32±10.64）U/L;P<0.001,血清胆红素则分别为（38.95±14.9）umol/L vs（22.33±10.9）umol/L,P<0.001。雅博司联...
- 肝硬化 /
- 肝性脑病 /
- 左旋门冬氨酸鸟苷酸 /
- 复方甘草酸苷
Abstract: To evaluate the efficacy of L-ornithine-L-aspartate (Hepa-Merz) with stronger neo-minophagen C (SNMC) for treatment of hepatic encephalogpahty of liver cirrhosis.80 patients with hepatic encephalopathy of liver cirrhosis were devided into two groups: group A were treated by intravenous infusion of L-ornithine-L-aspartate (Hepa-Merz) and SNMC;group B wered treated by intravenous infusion of sodium glutamate and SNMC, total course of treatment were 7 days.The levels of serum ammonia, ALT, AST and total bilirubin were detected before and after treatment.Serum ammonia in group A and group B whose before treatment and after treatment were 76.5±26.5 ummol/L vs 36.28±11.51 ummol/L and 71.58±16.99 ummol/L vs 49.8±16.46 ummol/L, (P<0.05) ;whereas the serum total bilirubin in group A and group B whose before and after were 40.05±15.12 ummol/L vs 20.95±11.27 ummol/L (P<0.001) and 38.95±14.9 ummol/L vs 22.33±10.9ummol/L (P<0.001) respectively.No serious side effects were found during the treatment.The combination of L-ornithine-L-aspartate (Hepa-Merz) with SNMC is a safe and effective treatment for hepatic encephalopathy of liver cirrhosis;besides, it decrease the level of serum ammonia and total bilirubin significantly.
- hepatic encephalopathy /
- liver cirrhosis /
- L-ornithine-L-aspartate (Hepa-Merz) /
- stronger neo-minophagen C (SNMC)

HTML全文

参考文献(5)

[1]Ferenci P, Lockwood A.Hepatic encephalopathy-definition, no-menclature, diagnosis, and quantification:final report of the workingparty at the 11th World Congresses of Gastroenterology, Vienna, 1998[J].Hepatology, 2002, 35 (3) ∶716-721.

[2]姚光弼.临床肝脏病学[M].上海:上海科技出版社, 2004∶281~296.

[3]陈立艳, 杨宝山, 马英骥, 等.复方甘草酸苷对小鼠暴发肝功能衰竭的保护作用[J].中华肝脏病杂志, 2005, 13 (3) ∶63-66.

[4]尹合坤, 李启祥, 谢汝缓, 等.左旋门冬氨酸鸟苷酸治疗非酒精性脂肪性肝炎的临床观察[J].中华全科医师杂志, 2004, 3 (3) ∶173-175.

[5]刘俊杰, 左旋门冬氨酸鸟苷酸在肝硬化合并肝性脑病中的应用观察[J].肝脏, 2005, 10 (3) ∶242-243.

施引文献

资源附件(0)

访问统计