慢性丙型肝炎患者血清IL-4、IFN-γ水平与病毒基因型、病毒量等抗病毒治疗影响因素的关系

苏峥; 姚希贤; 王军民; 白文元; 张新元

慢性丙型肝炎患者血清IL-4、IFN-γ水平与病毒基因型、病毒量等抗病毒治疗影响因素的关系

1. 上海市公共卫生临床中心
2. 河北医科大学第二附属医院
3. 河北省人民医院
4. 石家庄市传染病医院

详细信息

中图分类号: R512.6
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出版历程
- 出版日期: 2007-03-20

The relationship between the levels of serum IL-4 and IFN-γ and influence factors of anti-viral therapy for patients with chronic hepatitis C

摘要

摘要: 本研究检测了64例慢性丙型肝炎（CHC）患者的血清HCV RNA基因型、IFN-γ和IL-4水平、HCV-RNA含量以及ALT水平。结果显示CHC患者血清IFN-γ水平在1b型的患者显著低于2 a型（P<0.05）,与病毒载量、ALT水平等均无显著性相关（均为P>0.05）。在同一基因型中,血清IL-4、IFN-γ水平与ALT水平、病毒载量亦无相关（P>0.05）。在同一基因型中,血清IL-4、IFN-γ水平与ALT水平、病毒载量亦无相关（P>0.05）:在诸多抗病毒影响因素中,病毒基因型在血清IFN-γ水平上具有差别,提示1b型较其他基因型为低的IFN-γ水平可能是该型更易发生HCV持续感染的因素之一。
- 慢性丙型肝炎 /
- IL-4 /
- IFN-γ /
- 基因型 /
- 病毒量
Abstract: The genotype of hepatitis C virus, the levels of serum IFN-γ and IL-4, serum viral load and the level of ALT level were determined in the patients suffered from chronic hepatitis C.The level of serum IFN-γ from patients with genotype 1b was significantly lower than that from genotype 2a (P<0.05) .There was no correlation between the levels of serum IFN-γ and IL-4 and age, gender, serum ALT level or HCV RNA level (P>0.05) .And just in patients with the same genotype, there was no correlation between the levels of serum IFN-γ and IL-4 and the serum ALT level or HCV RNA level (P>0.05) .The low level of IFN-γ in the patients with genotype 1b might be a factor on sustained infection to hepatitis C virus.
- hepatitis C virus /
- IL-4 /
- IFN-γ /
- genotype /

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参考文献(4)

[1]中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8∶324-330.

[2]Torre D, Zeroli C, Giola M, et al.Serm levels of interleukin-1 al-pha, interleukin-1 beta, interleukin-6, and tumor necrosis factorin patients with acute viral hepatitis[J].Clin Infect Dis, 1994, 18∶194-8.

[3]Napoli J, Bishop GA, McGuinness PH, et al.Prog-ressive liver in-jury in chronic hepatitis C infectioncor-relates with increased intra-hepatic expression of Th1-associated cytokines[J].Hepatology, 1996, 24∶759-765.

[4]Karino Y, Toyota J, Sugawara M.Hepatitis C virus genotypes andhepatic fibrosis regulate 24-h decline of serum hepatitis C virusRNA during interferon therapy in patients with chronic hepatitis C[J].J Gastroenterol Hepatol, 2003, 18 (4) ∶404-410.

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