尿激酶型纤溶酶原激活物的表达与慢性重型肝炎预后的相关性

詹灵凌; 吕小平; 李山; 姜海行

尿激酶型纤溶酶原激活物的表达与慢性重型肝炎预后的相关性

基金项目:

广西科学基金资助项目(桂科基0342033、桂科基0143059)；

详细信息

中图分类号: R575.1
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出版历程
- 出版日期: 2007-03-20

Relationship between the prognosis of chronic severe hepatitis and the expression of urokinase-type plasminogen activator

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摘要

摘要: 探讨尿激酶型纤溶酶原激活物（Urokinase-type plasminogen activator,UPA）的表达与慢性重型肝炎的预后关系。我们对23例慢性重型肝炎患者采用Child-Pugh分级方法进行肝功能分级,并按存活与死亡分为存活组和死亡组。用酶联免疫吸附测定法（ELISA法）测定UPA。结果①慢性重型肝炎患者年龄小于50岁的UPA值（0.83±0.16）ng/ml,大于或等于50岁的UPA值（0.96±0.31）ng/ml,两组比较t=1.341,P>0.05;②a存活组UPA值（0.43±0.25）ng/ml,b死亡组UPA值（0.97±0.38）ng/ml,两组比较t=3.883,P<0.001。说明慢性重型肝炎患者的UPA表达与其年龄无关,而与其预后密切相关。
- 尿激酶型纤溶酶原激活物 /
- 慢性重型肝炎 /
- 肝纤维样变 /
- 肝细胞坏死 /
- 肝小叶改建
Abstract: To study the relationship between the prognosis of chronic severe hepatitis and the expression of urokinase-type plasminogen activator (UPA) .The liver functions of 23 cases with chronic severe hepatitis were classified according to Child-pugh.And these cases were divided into two groups, live group and death group.The level of UPA in the two groups was analyzed with ELISA.The results showed that there was not significantly different between the level of UPA in the cases over 50 age (0.83±0.16ng/ml) and in the cases below 50 age (0.96±0.31ng/ml) (t=1.341, P>0.05) .It also showed that the level of UPA in live group (0.43±0.25ng/ml) was significantly lower than that in death group (0.97±0.38ng/ml) (t=3.883, P<0.01) .It can be concluded that the UPA expression was closely related to the prognosis of chronic severe hepatitis, but not to age.
- urokinase-type plasminogen activator /
- chronic severe hepatitis /
- hepatofibrosis /
- hepatic cell necrosis /
- hepatic lobules change

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参考文献(5)

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