血清ALD和sE-Cad检测在TAE治疗原发性肝癌中的意义

劳明; 欧盛秋; 吴芸; 潘元平; 朱波; 黄文成

血清ALD和sE-Cad检测在TAE治疗原发性肝癌中的意义

1. 广西医科大学附属肿瘤医院
2. 广西中医学院第一附院

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中图分类号: R735.7
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出版历程
- 出版日期: 2007-02-20

The significance of the measurement of fructose 1, 6-disphosphate aldolase and soluble E-cadherin in transcatheter arterial embolization for hepatocellualcarcinoma

摘要

摘要: 为探讨血清1,6-二磷酸果糖醛缩酶（ALD）和可溶性上皮型钙粘蛋白（sE-Cad）检测对行经皮肝动脉灌注化疗栓塞术（TAE）治疗原发性肝癌疗效的临床价值,对46例原发性肝癌行TAE术后监测各阶段患者血清ALD、sE-Cad及甲胎蛋白（AFP）的变化并进行比较,结果显示,ALD活性变化反映了肝癌组织的坏死程度,sE-Cad及AFP水平随治疗进行呈下降趋势,ALD活性及sE-Cad水平术前、术后比较均有显著性差异P<0.05,血清ALD活性及sE-Cad水平检测均可用于TAE治疗原发性肝癌的疗效评价,特别是对AFP阴性的肝癌患者的疗效判断有较大的临床应用价值。
- 1,6-二磷酸果糖醛缩酶 /
- 可溶性上皮钙粘蛋白 /
- 原发性肝癌 /
- 经皮肝动脉灌注化疗栓塞术
Abstract: To evaluate the value of fructose 1, 6-Diphosphate Aldolase (ALD) and Soluble ECadherin (sE-Cad) on treating hepatocellular carcinoma (HCC) by transcatheter atterical Embolization (TAE) .There are 46 patients treated with TAE.The changes of serum levels of ALD and sE-Cad were analyzed in different stages after TAE.And the levels of the serum alpha-fetoprotein (AFP) were also analyzed.The results showed that the changes in serum levels of ALD indicated necrosis degree of tumor tissue in HCC.And the levels of sE-Cad and AFP in serum were reduced with developing of treatment.The levels of ALD and sE-Cad in serum there were obvious differentia after TAE treatment than before that (P<0.05) .Levels of ALD and sE-Cad in serum after TAE treatment were clinically useful to evaluate HCC, especially for the patients with low AFP.
- fructose 1 /
- 6-diphosphate aldolase /
- soluble E-cadherin /
- hepatocellular carcinoma

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参考文献(8)

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