Abstract: To investigate the role of prothrombin time (PT) and hepaplastin test (HPT) in evaluating liver fibrosis staging in patients with chronic hepatitis B.Seventy-two plasma samples from patients with chronic hepatitis B were detected for PT and HPT.Liver biopsy was performed in all patients.The values of PT and HPT in diagnosing liver fibrosis staging and early cirrhosis were compared.With degree of liver fibrosis increasing, the difference of PT between S0-S3 was not statistically significant.But it changed markedly in S4.The difference between S4 and S0, S1, S2 and S3 was statistically significant (P<0.01) . The difference of HPT between every two groups was statistically (P<0.01) , except between S0, S1 and S2.ROC analysis showed when 14.05 second, 19.05 second were used as the cut-off of PTs, HPTs for diagnosing S4, the sensitivity and specificity were 0.889, 0.814 and 0.889, 0.907 respectively.When 85.5%, 70.5% as the cut-off of PTA and HPTA for diagnosing S4, the sensitivity and specificity were 0.889, 0.814 and 0.889, 0.907 respectively.HPT and PT had some values in evaluating liver fibrosis staging.And the former was superior to the later.