Abstract: To investigate the clinical characteristics of patients with drug-induced liver disease and drugs resulting in the liver injuries.The medication taking history, clinical manifestation, liver function test and prognosis were analyzed comprehensively with retrospective review.Many drugs could induce liver disease.The traditional Chinese medicine accounted for 51.4% (56/109) .Among them, the drugs treating for skin disease and the bone joint system disease were the predominant.The western medicine accounted for 48.6% (53/109) , among which the most chief drugs were anti-inflammatory, antipyretic, antituberculotic and antithyroid drugs.The number of female patients (56.9%) was more than the male patients (43.1%) .The latent period varied 1-8 weeks.The most frequent clinical type was the hepatocellular damage type.The importance of the prevention, diagnosis and therapy of the disease should be emphasized, especially the disease which was induced by traditional Chinese medicine.