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Analysis of the factors influencing the prognosis of chronic severe hepatitis B
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摘要: 探讨影响慢性重型病毒性肝炎预后的因素。对172例慢性重型病毒性肝炎临床资料进行回顾性分析,总的病死率63.4%,与性别无关(P>0.05);年龄大于50岁者病死率为80.4%,预后差。病死组血清胆红素水平、HBV DNA阳性率、肝性脑病、电解质紊乱、肝肾综合征、上消化道出血、继发感染发生率明显高于好转或治愈组(P<0.01);凝血酶原时间(41.08±17.07)秒明显较好转组延长(27.06±7.84)秒,P<0.01。结果表明年龄≥50岁、高胆红素血症、凝血酶原时间延长、并发肝性脑病、电解质紊乱、消化道出血、肝肾综合征及继发感染是影响慢性重型肝炎预后的重要因素。
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关键词:
- 病毒性肝炎,重型,慢性 /
- 预后 /
- 流行病学因素
Abstract: To explore the prognosis factors on the patients with chronic severe hepatitis B by analyzing the clinical data of 172 cases with chronic severe hepatitis B retrosoectively.Fatality rate was 63.4% in patients with chronic severe hepatitis B, which had no relation to sexuality.Fatality rate was 80.4% in the patients older than 50 who had poor prognosis.In death group, serum bilirubin level, appearance of HBV DNA positive, hepatic encephalopathy, gastrointestinal hemorrhage, hepatorenal syndrome and secondary infection were higher than that in improvement group (P<0.01) .Prothrombin time (PT) in death group was significant higher than that in improvement group.Age older than 50-year, high serum bilirubin, long PT, complicated with hepatic encephalopathy, gastrointesinal hemorrhage, hepatorenal syndrome and infection are important factors influencing the prognosis of chronic severe hepatitis B.-
Key words:
- viral hepatitis /
- severe type /
- chronic
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[1]中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8∶324-326. [2]向德栋, 张盛, 王宇明, 等.477例重型病毒性肝炎预后影响因素分析[J].第三军医大学学报, 2001, 23 (6) ∶716-717. [3]Dhiman RK, Seth AK, Jain S, et al.Prognostice valuation of earlyindicator in fulminant hepatic failure multivariate analysis[J].DigDis Sci, 1998, 43 (6) ∶1311. [4]侯金林, 陈金军, 王战会, 等.乙型肝炎病毒毒株X基因/C基因启动子的热点变异[J].中华医学杂志, 1998, 78 (2) ∶107-110. [5]Chun YK, Kim JY, Woo HJ, et al.No significant correlation exitsbetween core promoter mutations, viral replication, and liver damagein chronic hepatitis B infection[J].Hepatology, 2000, 32∶1154-1162. -
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