PDF下载 ( 136 KB)
The protective effect of rhKD/APP on liver injured by D-galactosamine in rats
-
摘要: 用D-氨基半乳糖致大鼠肝损伤,以研究rhKD/APP对大鼠肝损伤的保护作用。建立D-氨基半乳糖大鼠肝损伤模型,设空白对照组、模型组、rhKD/APP小剂量组、中剂量组、大剂量组、对照药物抑肽酶组。观察大鼠血清丙氨酸转氨酶（ALT）、天门冬氨酸转氨酶（AST）、总蛋白（TP）、碱性磷酸酶（ALP）、白蛋白（ALB）及肝组织丙二醛（MDA）的含量变化。rhKD/APP可显著降低大鼠血清ALT、AST、ALP的活性及肝组织MDA含量,抑制ALB、TP的降低。rhKD/APP对D-氨基半乳糖所致大鼠肝损伤具有保护作用。Abstract: To investigate the protective effect of rhKD/APP on liver injured by D-galactosamine in rats.The rat liver injury model was induced by D-galactosamine.rhKD/APP was given by different dose, compared with controls and aprotinin.The levels of ALT, AST, TP, ALB, ALP in serum and MDA in hepatic tissue were mesured.rhKD/APP can significantly decresease the activities of ALT, AST, ALP, and the content of MDA, and inhibit the decrease of ALB and TP.rhKD/APP has a protective effect on liver injured by D-galactosamine in rats.
-
Key words:
- rhKD/APP /
- D-galactosamine /
- liver injury
-
[1]Lemaiemaire Kang J, Masters J M, Grzeschik L, et al.Alzheimer'sdisease amyloid A4 protein resembles a cell surface receptor[J].Na-ture, 1987, 325 (6160) ∶733. [2]贺巾超, 杨莉莉, 马杰, 等.rhKPI/AβPP大规模发酵及纯化工艺[J].吉林大学校报 (医学版) , 2006, 32 (2) ∶278. [3]贺巾超, 杨莉莉, 张馨木, 等.rhKPI/AβPP对四氯化碳致大鼠慢性肝损伤的保护作用[J].中国实验诊断学, 2006, 10 (8) ∶880. [4]Keppler D, Lesch R, Reutter W, et al.Experimental hepatitis in-duced by D-galactosamine[J].Exp Mol Pathol, 1968, 9 (2) ∶279~290. [5]杨龙飞, 金家兴, 赵晖, 等.清肝浸膏对D-氨基半乳糖致肝损伤模型大鼠肝功能及病理改变的影响[J].中国实验方剂学杂志, 2006, 12 (4∶) 40. [6]Lij, Sun M, Han M.NO, SOD and NOS in injuried liver of fetus ratwith intrauterine asphyxia[J].Shijie Huarenxiaohua Zazhi, 2002, 10 (2) ∶177~181. -
本文二维码
计量
- 文章访问数: 2051
- HTML全文浏览量: 14
- PDF下载量: 720
- 被引次数: 0
下载:
