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慢性乙型肝炎血清胰岛素样生长因子-1水平及其与血清肝纤维化指标关系的研究

陈志伟 叶晓光 于宪 黄远明 卓树洪

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慢性乙型肝炎血清胰岛素样生长因子-1水平及其与血清肝纤维化指标关系的研究

详细信息
  • 中图分类号: R512.62

Study on the level of insulin-like growth factor-1 and its relationship with serum markers of hepatic fibrosis in chronic hepatitis B

  • 摘要: 探讨各型慢性乙型肝炎(CHB)患者血清胰岛素样生长因子-1(IGF-1)的变化及其与血清肝纤维化指标的关系。用放射免疫分析法检测CHB和乙肝后肝硬化患者血清IGF-1和肝纤维化指标(包括HA、LN、PⅢP和CⅣ)。CHB和乙肝后肝硬化患者血清肝纤维化指标明显高于正常对照组,CHB患者血清IGF-1水平明显高于正常对照组,乙肝后肝硬化患者血清IGF-1水平则明显降低。CHB患者血清IGF-1水平与肝纤维化血清指标呈正相关,乙肝后肝硬化患者血清IGF-1水平与肝纤维化血清指标无相关关系。CHB患者血清IGF-1水平异常与肝脏的损害相关,而且可能与CHB患者肝脏纤维组织增生相关联。

     

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  • 出版日期:  2007-01-20
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