Analysis of liver histopathology in asymptomatic chronic HBV carriers
-
摘要: 了解ALT正常的HBV慢性携带者(ASC)的肝组织病理改变状况,探讨其临床意义及其与HBVDNA、HBeAg的关系。对32例ALT正常的HBV慢性携带者行快速经皮肝穿刺术取肝组织,研究肝组织炎症活动度及纤维化程度分级分期;ELISA法检测血清HBVM,PCR法检测血清HBVDNA。结果没有真正的健康ASC(病理状态为G0S0),32例ASC中,G1S0有15例,G1S1有13例,G2S1有4例;肝组织学的炎症活动及纤维化改变程度HBVDNA阳性组明显重于HBVDNA阴性组,男、女之间、HBeAg定性检测及HBVDNA水平的比较,无明显差异。
-
关键词:
- 慢性HBV携带者(ASC) /
- HBVDNA /
- 肝组织病理学 /
- 纤维化 /
- 炎症活动度
Abstract: To investigate the influences of serum HBVDNA and HBeAg levels on the changes and clinic values of liver histopathology in asymptomatic chronic hepatitis B virus carriers (ASC) .The changes of liver were evaluated histopathologically in 32 ASC by transepidermal liver biopsy method.The liver tissue was dyed with haematoxylin-eosin (HE) staining for study of pathologic grading and staging of hepatic liver inflammation and fibrosis.HBV-markers were detected by enzymelinked immunosorbent assay (ELISA) method.Serum HBVDNA levels were measured by polymerase chain reaction (PCR) method.It can be concluded that ASC are not absolute equal to health carriers.Of 32 carriers, there are 15 persons with G1S0, 13 persons with G1S1, 4 persons with G2S1.The rate of pathologic grading and staging of hepatic liver inflammation and fibrosis was not significantly changes in 20 male carriers compared with 12 female carriers (P>0.05) .The rate of those in HBVDNA (+) carriers showed significant different from those of HBVDNA (-) carriers (P<0.05) .The rate of those in HBeAg (+) and high copy groups (HBVDNA>1.0×107cp/ml) carriers showed no significant difference from those of HBeAg (-) and low copy groups (HBVDNA<1.0×107cp/ml) respectively (P>0.05) .-
Key words:
- asymptomatic chronic hepatitis B virus carrier /
- HBVDNA /
- HBeAg /
- liver histopathology /
- inflammation
-
[1]Maddrey WC.Hepatitis B:an important public health issue[J].JMed Virol, 2000, 61∶362-6. [2]Lin CL, Liao LY, Liu CJ.Hepatitis B genotypes and precore/basalcore promoter mutants in HBeAg-nepative chronic hepatitis B[J].JGastroenterol, 2002, 37 (4) ∶283-7. [3]彭文伟.现代感染性疾病与传染病学[M].北京:科学出版社, 2000∶617. [4]中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8 (6) ∶324. [5] 张光曙, 甘天福, 丁明权, 等.乙肝病毒标志与肝脏病理关系的观察[J].泰山卫生, 1999, 23 (4) ∶8-11. [6]赵学兰, 王宇明.乙型肝炎病毒前C区基因变异及其临床意义[J].国外医学.流行病学传染病分册, 2004, 31 (1) ∶31-33. [7] 骆抗先.乙型肝炎基础与临床[M].第2版.北京:人民卫生出版社, 2001∶318-9. [8]Chon CY, Han KH, Lee KS, et al.Peritoneoscopic liver biopsyfindings in asymptomatic chronic HBsAg carrier with normal liverfunction tests and no hepatomegaly[J].Yonsei Med J, 1996, 37∶295-301. [9]Agalar C, Diri C, Usubutun S, et al.The role of HBVDNAand liverhistopathology in HBsAg carrier[J].Hepato-gastroenterology, 1997, 44∶1196-9. [10]张斌, 金瑞, 陈恩华.肝功能正常的乙型肝炎病毒感染患者的肝组织病理结果分析[J].临床荟萃, 2004, 19 (1) ∶24-26. [11]杨柳明, 徐克成, 赵延龙, 等.肝活检对转氨酶正常的慢性乙型肝炎感染的临床意义[J].中华消化杂志, 2001, 21 (10) ∶590-1. [12] 张天舸, 许德军, 王春花, 等.HBV携带者的临床病理分析[J].中华临床新医学, 2003, 3 (10) ∶888-9. [13] 李庆彦.无症状乙肝病毒携带者的肝脏病理情况以及对保肝治疗的反应[C].山东大学硕士学位论文, 2002∶1-52. [14]徐玉敏, 周霞秋.肝活检的临床应用进展[J].实用医学杂志, 2002, (2) ∶203. [15]Bravo AA, Sheth S G, Chopla S.Livel biopsy[J].N Engl S Med, 2001, 344 (1) ∶495-500. [16]辛昭杰, 忘林杰, 毛远丽.病毒性肝炎肝纤维化的临床与病理研究[J].中华实验与临床病毒学杂志, 1997, 11 (4) ∶240-243. [17]马炬明, 钟阑, 江小肖.经皮肝穿刺活检组织检查578例[J].人民军医, 1997, 10 (7) ∶399. [18]林小田, 骆抗先, 冯筱容.慢性乙型肝炎临床与病理分级分期的对比分析[J].中华内科杂志, 1998, 37∶437-439.
本文二维码
计量
- 文章访问数: 2417
- HTML全文浏览量: 20
- PDF下载量: 829
- 被引次数: 0