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The relationship between non-alcoholic fatty liver disease and insulin resistance
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摘要: 探讨非酒精性脂肪肝(NAFL)发病与胰岛素抵抗的关系。对63例受检者用放免法测定血清胰岛素,稳态模型法计算胰岛素抵抗指数。同时选择20例无脂肪肝肥胖者作为对照组。脂肪肝组与对照组比较,血清胰岛素、胰岛素抵抗指数显著性增高(P<0.001),重度脂肪肝与中度脂肪肝、轻度脂肪肝比较,血清胰岛素、胰岛素抵抗指数也存在明显增高(P<0.05)。胰岛素抵抗可能系脂肪肝发病的原发因素,而非继发性改变。Abstract: To study the relationship between non-alcoholic fatty liver disease and insulin resistance.63 non-alcoholic fatty liver disease patients (male 35, femal 28) and 20 obesity without fatty liver disease were selected.Fasting serum insulin levels was measured by radio-immunoassay, insulin resistance index was estimated by the homeostasis model assessment (HOMA-IR) .Compared to controlgroup, patients with non-alcoholic fatty liver disease were characterized by hyperinsluinemia, elevated insulin resistance index (P<0.01) .Serum insulin and insulin resistance index were higher in heavy fatty liver disease patients than medium and light patients (P<0.05) .In the pathogeneses of non-alcoholic fatty liver disease, insulin resistance was an original factor probably and not a following changing.
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Key words:
- non-alcoholic fatty liver disease /
- obesity /
- Insulin resistance
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[1]Matthews DR, Hosker JP, Rudensk i AS, et al.Hom estasis modelassessm ent;insu lin resistance and B-cell function from fasting plas-ma glucose and insu lin concentration in man[J].D iabetologia, 1985, 28∶412~429. [2]中华医学会肝脏病学分会脂肪肝和酒精性肝病学组, 非酒精性脂肪性肝病诊断标准[J].中华肝脏病杂志, 2003, 11 (2) ∶71. [3]陈曦, 范建高.非酒精性脂肪肝:代谢综合征的另一个特征[J].实用肝病杂志, 2004, 2, 7 (1) ∶19~21. [4] 叶任高, 陆再英, 谢毅, 等.内科学[M].第6版。北京:人民卫生出版社, 2004∶813~814. [5] Day CP.Non-alcoholic steato hepatitis (NASH) :where are we nowand where are we going[J].Gut, 2002, 50 (5) ∶585~588. [6] 田浩明, 梁尽忠.糖尿病人血脂监测及临床应用[J].实用糖尿病杂志, 1995, 3 (6) ∶426. -
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