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The relationship between non-alcoholic fatty liver disease and insulin resistance
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摘要: 探讨非酒精性脂肪肝(NAFL)发病与胰岛素抵抗的关系。对63例受检者用放免法测定血清胰岛素,稳态模型法计算胰岛素抵抗指数。同时选择20例无脂肪肝肥胖者作为对照组。脂肪肝组与对照组比较,血清胰岛素、胰岛素抵抗指数显著性增高(P<0.001),重度脂肪肝与中度脂肪肝、轻度脂肪肝比较,血清胰岛素、胰岛素抵抗指数也存在明显增高(P<0.05)。胰岛素抵抗可能系脂肪肝发病的原发因素,而非继发性改变。Abstract: To study the relationship between non-alcoholic fatty liver disease and insulin resistance.63 non-alcoholic fatty liver disease patients (male 35, femal 28) and 20 obesity without fatty liver disease were selected.Fasting serum insulin levels was measured by radio-immunoassay, insulin resistance index was estimated by the homeostasis model assessment (HOMA-IR) .Compared to controlgroup, patients with non-alcoholic fatty liver disease were characterized by hyperinsluinemia, elevated insulin resistance index (P<0.01) .Serum insulin and insulin resistance index were higher in heavy fatty liver disease patients than medium and light patients (P<0.05) .In the pathogeneses of non-alcoholic fatty liver disease, insulin resistance was an original factor probably and not a following changing.
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Key words:
- non-alcoholic fatty liver disease /
- obesity /
- Insulin resistance
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