肝细胞肝癌微血管密度与雌激素受体表达的临床病理意义

张国栓; 崔专义; 郑志敏; 王桂琦; 秦素丽

肝细胞肝癌微血管密度与雌激素受体表达的临床病理意义

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中图分类号: R735.7
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出版历程
- 出版日期: 2006-03-20

Clinico-pathological significance of intratumoral microvessel density and estrogen receptor expression in hepatocellular carcinoma

摘要

摘要: 研究肝细胞肝癌（Hepatocellu lar Carc inom a,HCC）微血管密度（M icrovessel Density,MVD）与雌激素受体（Estrogen Receptor,ER）表达之间的关系,以及此二者与临床病理学特征之间的关系。36例HCC的患者分为ER（+）组和ER（-）组。按MVD值分为MVD<中位值组和MVD>中位值组,比较各组有预后意义的临床病理学参数之间的差别。ER（+）14例,ER（-）22例。全组MVD自3至121（44.67±32.15中位值为36）。ER（+）的HCC为直径较小、多有完整的包膜和较低的血清AFP浓度。MVD较低的HCC多为单结节、直径较小、细胞分化较好、血清AFP浓度较低。ER含量与MVD呈负相关。由此可见:（1）ER（+）或MVD较低的HCC分别比ER（-）或MVD较高的HCC恶性度较低。（2）ER与MVD均是有价值的预后指标。
- 肝细胞肝癌 /
- 微血管密度 /
- 雌激素受体
Abstract: To explore the relationship between intra tumoral microvessel density and estrogen receptor expression in hepatocellular carcinoma, and their relationship with the prognostic factors.36 patients with HCC were disparted into two groups: ER negative group and ER positive group.According to MVD value, they were disparted into MVDmedian group, and the established prognostic factors were compared.There were 14 ER (+) and 22 ER (-) cases, MVD value ranged from 3 to 121 (44.67±32.15 median=36) .Significant associations were found between ER status and tumor size, encapsulation and serum AFP concentration.Significant associations were found between MVD and the number of nodules, tumor size, Edmonson-Steiner class and serum AFP concentration.Inverse association was found between ER status and MVD.This shows: (1) ER positive or lower MVD in HCC has lesser malignant biological behavior than ER negative or higher MVD in HCC respectively. (2) Both ER status and MVD are good prognostic factors.
- hepatocellular carcinoma /
- microvessel density /
- estrogen receptor

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参考文献(9)

[1] Nagasue N, Ito A, YukayaH, et al.Estrogen receptors in hepatocel-lu lar carcinoma[J].Cancer, 1986, 57∶87~91.

[2]W eidner N.Current pathologic m ethods for m easuring intratumoralm icrovessel density w ith in breast carcinoma and solid tumors[J].B reast Cancer Res Treat, 1995, 36∶169~180.

[3] Nagasue N, Hohno H, chang YC, et al.C lin icopathologic compari-sons between estrogen receptor positive and negatire hepatocellu larcarcinoma[J].Ann Surg, 1990, 212∶150~154.

[4]任正刚, 杨秉辉, 叶胜龙, 等.雌激素受体与原发性肝癌生物学特性的关系.中华肿瘤杂志, 1999, 19∶10-13.

[5] The liver cancer study group of Japan.Pred ictive factors for long-term prognosis after partial hepatectomy for patients w ith hepatocellu-lar carcinoma in Japan[J].Cancer, 1994, 74∶2772-2780.

[6] Rogatsch H, H ittmair A, Reissigl A, et al.M icrovessel density incore b ioposies of prostatic adenocarcinoma:a stage pred ictor[J].JPathol, 1997, 182∶204-210.

[7] EL-Assal ON, Yamanoi A, Sola Y, et al.C lin ical sign ificance ofm icrovessel density and vascu lar endothelial growth factor expressionin hepatocellu lar carcinoma and surround ing liver:possib le involve-m ent of vascu lar endothelial growth factor in the angiogenesis of cir-rhotic[J].Hepatology, 1998, 27∶1554-1562.

[8] Hyder SM, Nawaz Z, Ch iappeta C, et al.Identification of functionestrogen response elem ent in the gene cod ing for the potent angiogen-esis factor vascu lar endothelial growth factor[J].Cancer`Res, 2000, 60∶3183-3190.

[9] L inderholm B, Tavelin B, CsrankvistK, et al.Vascu lar endothelialgrowth factor is of h igh prognostic value in node-negative breast car-cinoma[J].J C lin Oncol, 1998, 16∶3121~3128.

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