Abstract: To study the clinical characteristic and prognosis of hepatopulmonary syndrome (HPS) .The partial pressure of the arterial oxygen (PaO2) in 67 cases with live cirrhosis were examined by automatic blood gas analyzer.Of them 30 were classified as Child-Pugh A, 22 Child-Pugh B and 15 Child-Pugh C.23 cases of HPS confirmed by clinical data were reviewed.23 cases of HPS in 67 cases with live cirrhosis, the incidence of HPS is 34.3%.The incidence of HPS is related with Child-Pugh grade.Compared the Child-Pugh C with Child-Pugh A, the incidence of HPS is significant (P<0.05) .Compared HPS that have different portal vein bore, have esophageal and gastric varices or not, have spider nevus or not, the incidence is significant (P<0.05) .7 cases in 23 cases HPS has died.HPS is not direct dead cause.The constellation of clinical findings of portal hypertension, spider nevus is strongly suggestive of HPS.The initial diagnosis and treatment HPS are conducive to relieve hypoxemia and improve patient prognosis.