The influence of histamine and endotoxins to the quilibration of Th1/Th2 in patients with chronic HBV infection
-
摘要: 通过研究CHB(慢性乙型肝炎)患者血浆组胺、ET(内毒素)与Th1、Th2类细胞因子的关系,进而探讨其对CHB患者免疫功能的影响。以鲎试剂法测定血浆ET,以荧光法测定血浆组胺水平,分析ET、组胺与Th1、Th2类细胞因子的关系。CHB患者均有不同程度的Th1/Th2类细胞因子失衡,主要表现为:Th1类细胞因子减少而Th2类细胞因子增加,ET主要影响Th2类细胞因子,组胺影响Th1类细胞因子。Abstract: To study the relationship between plasma ET、histamine and Th1/Th2 cytokines in patients of CHB;To further explore wether they have influence to immunological function.The plasma and serum were collected from patients of CHB and normal human, the correlation of the ET、histamine and Th1/Th2 cytokines was analysed.There are Th1/Th2 imbalance of different gradients in patients of CHB.ET and histamine are correlate with immunological function, but they produce a marked effect in different ways.ET make sTh2 cytokines increased, while histamine make sTh1 cytokines decreased.
-
Key words:
- chronic HBV infection /
- histamine /
- endotoxin /
- cellular immunity
-
[1]中华医学会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19∶56-62. [2]吴晓蔓, 郭海波.慢性乙型肝炎患者血清IL-10与HBV DNA复制水平检测及临床意义[J].临床肝胆病杂志, 2004, 20 (3) ∶151-152. [3] E lenkov IJ, W ebsterDA, Papan icolaou TA, et al.H istam ine potent-ly suppresses human IL-12 and stimu lates IL-10 production viaH2receptors[J].J Immunol, 1998, 161∶2586-2593. [4]赵龙凤, 李红, 韩德五.肠源性内毒素血症与肝病[J].世界华人消化杂志, 2000, 8 (10) ∶1145-1149.
本文二维码
计量
- 文章访问数: 2039
- HTML全文浏览量: 25
- PDF下载量: 839
- 被引次数: 0