慢性乙型肝炎患者肝功能与血清HBVDNA负荷及肝脏病理的关系

丁虹; 陆忠华; 蒋祥虎

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慢性乙型肝炎患者肝功能与血清HBVDNA负荷及肝脏病理的关系

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2006-03-20

The relationship between the liver function and contents of serum HBVDNA and hepatic pathology in patiens with chronic hepatitis B.

摘要

摘要: 探讨慢性乙型肝炎患者肝功能与血清HBVDNA负荷及肝脏病理的相关性。随机选择207例慢性乙型肝炎患者,检测其血清ALT、HBVDNA含量,肝穿刺活检,光镜多视野观察其肝组织的病理情况。随着慢性乙型肝炎患者血清ALT的升高,HBVDNA复制程度的增高,其肝组织的炎症活动度、纤维化程度明显升高(P<0.01)。慢性乙型肝炎患者血清ALT、HBVDNA含量与肝组织的炎症活动度、纤维化程度有相关性。
- 慢性乙型肝炎 /
- 肝组织 /
- 乙型肝炎病毒脱氧核糖核酸 /
- 肝功能
Abstract: To study on the relationship between the liver function and contents of serum HBVDNA and hepatic pathology in patiens with chronic hepatitis B.207 cases patiens with chronic hepatitis B collected by randam sampling method.Deteor their ALT and the HBVDNA in the serum and examined the liver tissue with pathological methods.Followed by the elevation of ALT and HBVDNA in the serum the liver tissnes inflammation actirity and fibrosis was obviously elevated.The result showed that the ALT in serum and the contents of HBVDNA in serum was correlated with the liver Inflammation activity and fibrosis of the patients with chronic hepatitis B (P<0.01) .
- chronic hepatitis B /
- liver tissue /
- HBVDNA /
- liver function

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参考文献(3)

[1]王虹, 成万松, 王省良, 等.乙型肝炎患者HBVDNA定量测定与临床疗效的关系[J].中华肝脏病杂志, 2000, 8 (4) ∶255.

[2]刘伟, 赵伟, 罗婵, 等.乙型肝炎患者血清和肝组织中HBVDNA检测分析[J].临床肝胆病杂志, 2005, 21 (1) ∶12~13.

[3] L iaw YF, Levine MD, L iotta LA, et al.StimuLation and requ lationof tunor ceu motility in invation and m etastad is[J].Gastroteru logy, 1994, 81∶1047~1053.

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