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Detect on serum thrombopoietin levels in patients with liver cirrhosis and it's clinic significance
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摘要: 探讨肝硬化患者血清血小板生成素（TOP）浓度与血小板减少的关系。用酶联免疫吸附法（ELISA）测定肝硬化肝功能代偿期、失代偿期以及正常人血清TPO浓度。血清TOP浓度正常人、肝硬化肝功能代偿期、失代偿期分别为（136.24±68.56）pg.m l-1、（124.34±41.31）pg.m l-1和（59.05±52.77）pg.m l-1。肝硬化肝功能失代偿期的血清TPO浓度较正常人明显降低（t=4.04,P<0.001）;正常人的血清TPO浓度受外周血小板计数的调节,而肝硬化患者的血清TPO浓度与外周血小板计数之间无明显相关而与血清白蛋白浓度呈正相关（r=0.86,P<0.001）、血清总胆红素浓度呈负相关（r=0.49,P<0.05）。肝细胞产生TPO不足可能是肝硬化发生血小板减少的主要原因。血清TPO浓度可能是评价肝硬化患者肝功能的有用指标。Abstract: To observe the relationship on serum thrombopoietin (TPO) levels and thrombocytopenia in patients with liver cirrhosis and it's significance in liver function evaluation.Serum TPO levels in patients with liver cirrhosis (liver function compensative or decompensative) and normal controls were detected by ELISA.The serum TPO levels of normal controls, patients with compensative liver function and patients with decompensative liver function were (136.24±68.56) pg·ml-1, (124.34±41.31) pg·ml-1 and (59.05±52.77) pg·ml-1 respectively.The TPO level of patients with decompensative liver function was significantly lower than that of normal controls (t=4.04, P<0.001) .In the patients with liver cirrhosis, the serum TPO level was correlated with serum concentration of album (r=0.86, P<0.001) and negative correlated with serum concentration of tatol bilirubin (r=-0.49, P<0.05) .Insufficient of TPO production in liver maybe the main cause of thrombocytopenia in the patients with liver cirrhosis.The serum TPO level maybe a useful item to evaluate liver function of the patients with liver cirrhosis.
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Key words:
- liver cirrhosis /
- thrombopoietin /
- thrombocytopenia
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[1]Nomura S, Ogam i K, Kawamura K, et al.Cellu lar localization ofthrombopoietin mRNA in the liver by in situ hybrid ization[J].ExpHematol, 1997, 25 (7) ∶565-572. [2]徐希岳, 王启之, 田怡.肝炎后肝硬化脾功能亢进时的骨髓象变化[J].临床肝胆病杂志, 1990, 6 (4) ∶207-208.0 [3] 朱美伦, 杨建营, 张慧香, 等.乙型肝炎患者血小板减少机制探讨[J].临床肝胆病杂志, 1991, 7 (3) ∶157-159. [4]Sh imodaira S, Ish ida F, Ich ikawa N, et al.Serum thrombopoietin (c-mpl ligand) levels in patients w ith liver cirrhosis[J].Thromb Hae-most, 1996, 76 (4) ∶545-548. [5]Peck RM, Zacherl J, W ichlasM, et al.Thrombopoitic cytok ins andreversal of thrombocytopen ia after liver transplantation[J].Eur JGastroenterolHepatol, 1999, 11 (2) ∶151-156. [6]Matin TG, Somberg KA, M eng YG, et al.Thrombopoietin levels inpatients w ith cirrhosis before and after orthotop ic liver transplatation[J].An Intern M ed, 1997, 127 (8) ∶285-289. -
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