肝硬化患者肠通透性及乳果糖对其影响的研究

于淑霞; 王惠吉

肝硬化患者肠通透性及乳果糖对其影响的研究

1. 北京市大兴区人民医院
2. 首都医科大学附属北京友谊医院

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中图分类号: R575.2
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出版历程
- 出版日期: 2006-02-20

Intestinal permeability in patients with liver cirrhosis and effects of lactulose on it

摘要

摘要: 研究肝硬化患者肠通透性特点;肠通透性与内毒素血症的关系以及乳果糖对肠通透性和内毒素血症的作用。实验分两部分,第一部分研究肝硬化患者肠通透性特点。肝硬化组测定血二胺氧化酶(d iam ine oxidaseDAO)、血内毒素。正常对照组检查血二胺氧化酶。第二部分行乳果糖干预治疗的研究。入选的肝硬化患者随机分乳果糖治疗组和非乳果糖治疗组,两周后重复检查血清DAO和血清内毒素。肝硬化患者内毒素血症阳性率为73.8%,血DAO水平均较正常对照增加,血清内毒素水平与血DAO水平呈线性正相关。腹水患者较无腹水者血DAO和血内毒素水平高,组间有显著性差异。乳果糖治疗后血清DAO水平及血内毒素水平较治疗前有显著降低。
- 肝硬化 /
- 肠通透性 /
- 二胺氧化酶 /
- 乳果糖 /
- 内毒素血症
Abstract: To study the characteristic of intestinal permeability in patients with liver cirrhosis and the efficacy of lactulose on intestinal permeability and endotoxemia.The study was divided into two parts.First one is to study intestinal permeability in cirrhosic patients.patients with cirrhosis and healthy control subjects was involed in it.Serum diamine oxidase (DAO) , serum endotoxin was determined in patients with cirrhosis, Only diamine oxidase (DAO) was determined in the normal controlls.The second part is effects of lactulose on intestinal permeability and endotoxemia.Patients was divided into two groups randomly.Lactulose was given orally and cirrohsis was treated in lactulose group.Lactulose was not given in non lactulose one.Serum diamine oxidase (DAO) , serum endotoxin was determined again after two weeks.Endotoxemia occurred in majority of patients with cirrhosis (73.8%) , Serum DAO is higher in patients than in control subjects.Serum endotoxin is liner correlative with serum DAO.Serum endotoxin and serum DAO are higher in patients with ascites than patients without.Both Serum DAO and endotoxin are lower after lactulose treatment than before.
- liver cirrhosis /
- intestinal permeability /
- diamine oxidase /
- lactulose /
- endotoxemia

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参考文献(10)

[1]F ink MP.Gastrointestinal muosal in jury in experim ental model ofshock, trauma and sepsis[J].C rit Care M ed, 1991, 19 (5) ∶627-640.

[2]Lunn PG, Northrop, C lewes CA, et al.Intestinal perm eab ility, mu-cosal in jury, and growth faltering in Gamb ian infants[J].Lancet, 1993, 338 (8772) ∶907-910.

[3] Luk GD, Bayless TM, Baylin SB.D iam ine oxidese (H istammase) .A circu latingmarker for rat intestinalmucosalmaturation and integri-ty[J].J clin ical investingation, 1980, 66 (1) ∶66-70.

[4]Luk GD, Bayless TM, Baylin SB.P lasma postheparin d iam ine ox-idese sensitive provocative test for quantitating length of acute intesti-nalmucosal in jury in the rat[J].Journal of clin ical investingation, 1983, 71 (5) ∶1305-1308.

[5]陈秀凯, 邱方, 程爱国.肠道屏障功能的监测方法的现状与进展[J].中国煤炭工业医学杂志, 2003, 6 (7) ∶669-671.

[6]L in RS, Lee FY, Lee SD, et al.Endotoxem ia in patientsw ith chron-ic liver d isease∶Ralationsh ip to severity of liver d iseases, presence ofesophageal varices, and hyperdynam ic circu lation[J].J Hepatol, 1995, 22 (2) ∶165-72.

[7]王锦辉, 陈氵湖, 孙光裕, 等.肝硬化患者小肠细菌过度生长与内毒素血症[J].中华内科杂志, 2002, 41 (7) ∶459-461.

[8]张顺才, 王唯, 任卫英, 等.西沙必利对肝硬化大鼠小肠细菌及内毒素转位的影响[J].中华肝脏病杂志, 2003, 11 (9) ∶539-541.

[9]Madrid AM, Hurtado C, Venegas M, et al.Long-term treatm entw ith cispride and antib iotics in liver cirrhosis∶effect on small intes-tinal motility, bacterial overgrwth, and liver function[J].Am J Gas-troenterol, 2001, 96 (4) ∶1251-1255.

[10]刘仁宽, 温朗聪, 王崇霞.乳果糖研究进展[J].中国微生态学杂志, 1997, 9 (3) ∶62-64.

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