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摘要: 分析IL-18、IL-4、IFNγ在慢性乙型重型肝炎中的作用。采用固相夹心法酶联免疫吸附试验检测25例正常人,35例慢性乙型肝炎,45例慢性乙型重型肝炎患者血清IL-18、IL-4、IFNγ的水平。结果发现1.IL-18、IL-4三组间均有显著性差异,IFNγ慢性肝炎与慢重肝无显著性差异,但均显著高于正常对照组;2.IL-18、IL-4生存组显著低于死亡组(P<0.05),IFNγ两组间无显著性差异;3.重型肝炎重症期与康复期比较,IL-18、IFNγ康复后均显著性下降(P<0.05);4.慢重肝组IL-4与IL-18呈正相关(r=0.6,P<0.01);IL-4与IFNγ呈正相关(r=0.54,P<0.01)。IL-18、IL-4、IFNγ参与了重型肝炎的发病及转归过程,在慢性重型肝炎的免疫病理中有重要作用。
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