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CyclinD1、CyclinE、CDK6在原发性肝细胞癌中的表达

郑美蓉 阮庆大 程玲 胡志红 梁淑凡 吴萍

引用本文:
Citation:

CyclinD1、CyclinE、CDK6在原发性肝细胞癌中的表达

基金项目: 

江西省卫生厅基金资助课题(2002-17); 

详细信息
  • 中图分类号: R735.7

Expression of cyclin D1 cyclin E and CDK6mRNA in hepatocellular carcinoma

Research funding: 

 

  • 摘要: 探讨细胞周期调控因子CyclinD1、CyclinE、CDK6在原发性肝细胞癌中的表达及意义。应用免疫组织化学、原位分子杂交和细胞图象分析技术检测原发性肝细胞癌组织及其对应的癌旁肝组织(各20例)、正常肝组织(5例)中CyclinD1、CyclinE和CDK6mRNA表达情况。结果显示:CyclinD1、CyclinE和CDK6mRNA在肝细胞癌组织中呈阳性表达,阳性率分别为70%、75%和25%,正常肝组织呈阴性表达;肝细胞癌组织中CyclinD1和CyclinE的阳性表达与癌旁肝组织、正常肝组织相比,差异均有显著性意义(P<0.05);CyclinD1和CyclinE的过表达在肝细胞癌的发生和发展中起着重要作用。

     

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  • 出版日期:  2006-01-20
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