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The clinical significance of serum leptin levels in patients with nonalcoholic fatty liver
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摘要: 研究非酒精性脂肪肝患者血清瘦素水平检测的临床意义。选择门诊或住院患者非酒精性脂肪肝30例,正常对照30例,采用放射免疫法检测血清瘦素及胰岛素水平。结果发现,脂肪肝患者血清瘦素(23.7±13.1)μg/ml,胰岛素水平、(16.7±4.9)μg/ml显著高于正常对照组(4.7±3.2)μg/ml及(9.7±2.6)μg/ml,P<0.001。无论脂肪肝组还是正常对照组,血清瘦素水平升高存在性别差异,女性明显高于男性。脂肪肝患者存在瘦素抵抗和胰岛素抵抗,早期检测血清瘦素水平,为早期干预治疗脂肪肝提供了可能的途径。Abstract: To study the clinical significance of serum leptin levels in patients with nonalcoholic fatty liver.The serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver.The serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver and 30 normal controls were determined by means of radioimmnuoassay.We found that the serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver (23.7±13.1μg/ml, 16.7±4.9μg/ml) were higher than those of controls (4.7±3.2μg/ml, 9.7±2.6μg/ml) , P<0.001.The serum leptin levels in women patient were higher than those in man patients in the two groups.Leptin resistance and insulin resistance exist in the patients with nonalcoholic fatty liver.Early detection of serum leptin levels provide a possible way for early intervention of nonalcoholic fatty liver.
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Key words:
- Nonalcoholic fatty liver /
- leptin /
- insulin
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为使作者了解本刊的编辑出版计划，及时惠赐稿件，《临床肝胆病杂志》编委会确定了2023年1-12期“重点号”选题及各期执行主编：
1期 扩大慢性乙型肝炎抗病毒治疗……………………………………………………………………………………………………………庄辉
2期 中医药抗肝纤维化的近期和远期目标……………………………………………………………………………………………………李秀惠
3期 肝脏病理和肝病精准诊治…………………………………………………………………………………………………………………杨永峰
4期 重视丁型肝炎病毒感染……………………………………………………………………………………………………………………庄辉
5期 肝病的细胞治疗……………………………………………………………………………………………………………………………王贵强
6期 慢性乙型肝炎及其一体化防治的中医、中西医结合治疗——从“十一五”到“十三五”的回顾与展望……………………………………………………………………………………………………………叶永安
7期 门静脉高压症的介入诊疗进展……………………………………………………………………………………………………………朱晓黎
8期 代谢相关脂肪性肝病新认识………………………………………………………………………………………………………………范建高
9期 胆道肿瘤的精准诊疗………………………………………………………………………………………………………………………曾永毅
10期 慢加急性肝衰竭的临床分型及预后评估…………………………………………………………………………………………………陈煜
11期 戊型肝炎精准诊疗新进展…………………………………………………………………………………………………………………曹红翠
12期 胰腺病相关消化不良诊治…………………………………………………………………………………………………………………傅德良
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《临床肝胆病杂志》编辑部 2023年5月20日 -
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