PDF下载 ( 132 KB)
The clinical significance of serum leptin levels in patients with nonalcoholic fatty liver
-
摘要: 研究非酒精性脂肪肝患者血清瘦素水平检测的临床意义。选择门诊或住院患者非酒精性脂肪肝30例,正常对照30例,采用放射免疫法检测血清瘦素及胰岛素水平。结果发现,脂肪肝患者血清瘦素(23.7±13.1)μg/ml,胰岛素水平、(16.7±4.9)μg/ml显著高于正常对照组(4.7±3.2)μg/ml及(9.7±2.6)μg/ml,P<0.001。无论脂肪肝组还是正常对照组,血清瘦素水平升高存在性别差异,女性明显高于男性。脂肪肝患者存在瘦素抵抗和胰岛素抵抗,早期检测血清瘦素水平,为早期干预治疗脂肪肝提供了可能的途径。Abstract: To study the clinical significance of serum leptin levels in patients with nonalcoholic fatty liver.The serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver.The serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver and 30 normal controls were determined by means of radioimmnuoassay.We found that the serum leptin, insulin levels in 30 patients with nonalcoholic fatty liver (23.7±13.1μg/ml, 16.7±4.9μg/ml) were higher than those of controls (4.7±3.2μg/ml, 9.7±2.6μg/ml) , P<0.001.The serum leptin levels in women patient were higher than those in man patients in the two groups.Leptin resistance and insulin resistance exist in the patients with nonalcoholic fatty liver.Early detection of serum leptin levels provide a possible way for early intervention of nonalcoholic fatty liver.
-
Key words:
- Nonalcoholic fatty liver /
- leptin /
- insulin
-
[1]Uygun A, Kadayifci A, Yesilova Z, et al. Serum leptin levels in patients with nonalcoholic steatohepatitis[J].Am J Gastroenterol, 2000, 95 (12) ∶3584-9. [2]Faggioni R, Jones-Carson J, Reed DA, et al.Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity∶role of tu-mor necrosis factor alpha and IL-18[J].Proc Natl Acad Sci USA, 2000, 97 (5) ∶2367-72. [3]Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease∶ a feature of the metabolic syndrome[J]. Diabetes, 2001, 50 (8) ∶1844-50. [4]Wabitsch M, Blum WF, Muche R, et al.Contribution of androgens tothe gender difference in leptin production in obese children and adoles-cents[J].J Clin Invest, 1997, 100 (4) ∶808-13. [5] Kaplan LM. Leptin, obesity, and liver disease [M]. Gastroenterology, 1998∶115 (4) ∶997-1001. [6]Chitturi S, Farrell G, Frost L, et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis∶ a manifextation of lipotoxicity[J]? Hepatology, 2002, 36 (2) ∶403-9. [7]Campillo B, Sherman E, Richardet JP. Serum leptin levels in alcoholic liver cirrhosis∶ relationship with gender, nutritional status, liver function and energy metabolism[J]. Eur J Clin Nutr, 2001, 55 (11) ∶980-8. -
本文二维码
计量
- 文章访问数: 2061
- HTML全文浏览量: 7
- PDF下载量: 794
- 被引次数: 0
下载:
