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瘦素抵抗与男性非酒精性脂肪肝的关系

卢震亚 王群燕 饶伟强 蔡卫民

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瘦素抵抗与男性非酒精性脂肪肝的关系

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  • 中图分类号: R575.5

Relationship between leptin resistance and nonalcoholic fatty liver in male patients.

  • 摘要: 研究瘦素抵抗和男性非酒精性脂肪肝(nonalcoholic fatty liver,NAFL)的关系。我们用放射免疫法检测52例NAFL患者和45例正常对照者血清中的瘦素水平,分析血清瘦素与男性NAFL患者以及与HOMA-IR(以HOMA模型计算胰岛素抵抗指数)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)等指标的关系。NAFL患者血清中的瘦素水平(6.75±1.32μg/ml)显著高于正常对照组(3.21±0.95μg/ml),P<0.01,且肥胖的NAFL患者血清中的瘦素水平(7.95±0.85ng/ml)显著高于非肥胖NAFL患者的瘦素水平(6.11±1.21μg/ml),P<0.01。NAFL患者血清中的FINS、HOMA-IR和TG水平均高于正常对照组,且NAFL患者血清瘦素水平与HOMA-IR呈负相关(r=0.521,P<0.05),与BMI呈正相关(r=0.718,P<0.00),与TG呈正相关(r=0.425,P<0.01)。男性NAFL患者存在着明显的瘦素抵抗,提示瘦素抵抗在NAF...

     

  • [1]Marchesini G, Brizi M, Bianchi G, et al.Metformin in non-alcoholicsteatohepatitis[J].Lancet, 2001, 358 (9285) ∶893-894.
    [2]Uygun A, Kadayifci A, Yesilova Z, et al.Serum leptin levels in patientswith nonalcoholic steatohepatitis[J].Am J Gastroenterol, 2000, 95 (12) ∶3584-3589.
    [3]Bloks VW, Plosch T, Van-Goor H, et al.Hyperlipidemia andatherosclerosis associated with liver disease in ferrochelatase-deficientmice[J].J Lipid Res, 2001, 42 (1) ∶41-50.
    [4]Santos Alvarez J, Goberna R, Sanchez-Margalet V.Human Leptinstimulates proliferation and activation of human circulating monocytes[J].Cell Immunol, 1999, 194 (1) ∶6-11.
    [5]Tobe K, Ogura T, Tsukamoto C, et al.Relationship between serum leptinand fatty liver in Japanese male adolescent university students[J].Am JGastroenterol, 1999, 94 (11) ∶3328-3335.
    [6]朱惠娟, 史铁蘩, 胡明明, 等.减重治疗逆转超重及肥胖症患者脂肪肝的作用[J].中华内科杂志, 2003, 42 (2) ∶98-102.
    [7]Zhang Y, Proenca R, Maffei M, et al.Positional cloning of the mouseobese gene and its human homologue[J].Nature, 1994, 372 (6505) ∶425-432.
    [8]Bartek J, Bartos J, Galuska J, et al.Expression of ob gene coding theproduction of the hormone leptin in hepatocytes of liver with steatosis[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2001, 145 (1) ∶15-20.
    [9]Lewandowski K, Horn R, Ocallaghan CJ, et al.Free leptin, bound lep-tin, and soluble leptin receptor in normal and diabetic pregnancies[J].JClin Endocrinol Metab, 1999, 84 (1) ∶300-306.
    [10] Koteish A, Dieh1 AM.Animal models of steatosis[J].Semin LiverDis, 2001, 21 (1) ∶89-104.
    [11]Giannini E, Botta F, Cataldi A, et al.Leptin levels in nonalcoholicsteatohepatitis and chronic hepatitis C[J].Hepatogastroenterology, 1999, 46 (28) ∶2422-2425.
    [12]Giannini E, Botta F, Cataldi A, et al.Leptin levels in nonalcoholicsteatohepatitis and chronic C[J].Hepatogastroenterology, 1999, 46 (28) ∶2422-2425.
    [13]Chehab FF, Lim ME, Lu R.Correction of the sterility defect in ho-mozygous obese female mice by treatment with the human recombinantleptin[J].Nat Genet, 1996, 12 (3) ∶318-320.
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  • 出版日期:  2006-01-20
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