TGF-β1的ERK通路及其抑制剂与纤维化

宋雅芳; 洪嘉禾; 徐列明

TGF-β1的ERK通路及其抑制剂与纤维化

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中图分类号: R575.2
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出版历程
- 出版日期: 2005-02-20

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参考文献(12)

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[3] AxmannA , SeidelD , ReimannT , etal.Transforminggrowthfactorbetal-inducedactivationoftheRaf-MEK -MAPKsignalingpathwayinratlungfibroblastsviaaPKC -dependentmechanism[J].BicohemBiophysResCommun, 1998, 249 (2) ∶456-460.

[4] FinlayGA , ThannickalVJ , FanburgBL , etal.Transforminggrowthfactor-beta1-inducedactivationoftheERKpathway/activatorprotein-1inhumanlungfibroblastsrequirestheautocrineinductionofbasicfibroblastgrowthfactor[J].JBiolChem, 2000, 275 (36) ∶27650-27656.

[5] StrattonR , RajkumarV , PonticosM , etalProstacyclinderivativespreventthefibroticresponsetoTGF -betabyinhibitingtheRas/MEK/ERKpathway[J].FASEBJ, 2002, 16 (14) ∶1949-1951.

[6] HayashidaT , PonceletAC , HubchakSC , etal.TGF -betalactivatesMAPkinaseinhumanmesangialcells∶apossibleroleincollagenexpression[J].KidneyInt, 1999, 56 (5) ∶1710-1720.

[7] KutzSM , HordinesJ, McKeown-LongoPJ, etal.TGF -betal-inducedPAI-1geneexpressionrequiresMEKactivityandcell-to-substrateadhesion[J].JCellSci, 2001, 114 (Pt21) ∶3905-3914.

[8] InokiK , HanedaM , IshidaT , etal.Roleofmitogen-activatedproteinki nasesasdownstreameffectorsoftransforminggrowthfactor-betainmesangialcells[J].KidneyIntSuppl, 2000, 77∶S76-80.

[9] IsonoM , CruzMC , ChenS , etal.Extracellularsignal-regulatedkinasemediatesstimulationofTGF -betalandmatrixbyhighglucoseinmesan gialcells[J].JAmSocNephrol, 2000, 11 (12) ∶2222-2230.

[10] YonekuraA , OsakiM , HirotaY , etal.Transforminggrowthfactor-betastimulatesarticularchondrocytecellgrowththroughp44/42MAPkinase (ERK) activation[J].EndocrJ, 1999, 46 (4) ∶545-553.

[11] TokudaH , HatakeyamaD , AkamatsuS , etal.InvolvementofMAPkinas esinTGF -beta-stimulatedvascularendothelialgrowthfactorsynthesisinosteoblasts[J].ArchBiochemBiophys, 2003, 415 (1) ∶117-125.

[12] HayashidaT , DecaesteckerM , SchnaperHW .Cross-talkbetweenERKMAPkinaseandSmadsignalingpathwaysenhancesTGF -beta-depen dentresponsesinhumanmesangialcells[J].FASEBJ, 2003, 17 (11) ∶1576-1578.

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