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Study on the linkage between variation of YMDD in hepatitis B virus and hepatic fibrosis serum markers
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摘要: 为了阐明乙型肝炎病毒YMDD变异对肝纤维化的影响。 4组共 170例患者治疗 (或观察 )前后分别用实时荧光PCR法检测其外周血中的HBVDNA及YMDD变异株 ,用RIA法检测肝纤维化血清指标。治疗后未变异组与变异组比较肝纤维化血清指标差异不显著 (P >0 0 5 ) ,其它组之间比较差异有显著意义 (P <0 0 5 ) ,各组治疗前后比较血清HBVDNA及肝纤维化血清指标差异有显著意义 (P <0 0 5 )。结果显示拉米夫定能有效地抑制HBV复制 ,延缓或逆转肝纤维化进程 ,但是 ,YMDD变异使其对HBV复制的抑制作用减弱 ,延缓或逆转肝纤维化进程的作用也受影响Abstract: To expound the influence of the variation of YMDD in hepatitis B virus on the hepatic fibrosis. 4 groups (170 sera samples) were detected HBV DNA and YMDD mutation in serum by real-time fluorimetry PCR between pretreatment and post-treatment. They were detected hepatic fibrosis serum markers by RIA. There was no significant difference in the hepatic fibrosis serum markers between the group of non variation and variation at post-treatment (P>0.05) . There was a significant difference among the other groups (P<0.05) . Each group had a significant difference in the HBV DNA contents in sera and hepatic fibrosis serum markers between at the beginning and end of treatment (P<0.05) . The result showed that Lamivudine could efficaciously control HBV's reproduction, postpone or reverse hepatic fibrosis developing. But the Variation of YMDD would affect its curative effect.
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Key words:
- Hepatitis B virus /
- Variation of YMDD /
- Hepatic fibrosis /
- Polymerase chain reaction
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[1] 中华医学会传染病与寄生虫病学分会、肝病学分会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19∶56-62. [2]刘传苗, 张欣欣, 张东华, 等.实时荧光聚合酶链反应检测乙型肝炎病毒聚合酶基因变异[J].中华检验医学杂志, 2003, 26∶37-39. [3]俞纯山.肝纤维化的检测及其临床意义[J].中华检验医学杂志, 2000, 23∶190-192. [4] LaiCL , ChienRN , LeungNW , etal.Aone-yeartrialofLamivudineforChronichepatitisB[J].EnglJMed, 1998, 339 (2) ∶61-68. [5] OmataM .TreatmentofchronichepatitisBinfection[J].NEnglJMed, 1998, 339 (2) ∶114-1155. -
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