Influence of serum TGF-β1 on cellular immune function in patients with chronic hepatitis B
-
摘要: 观察慢性乙肝、肝硬化患者血清TGF - β1和T淋巴细胞亚群的关系 ,探讨TGF - β1对慢乙肝细胞免疫功能的影响。以ELISA法测定 83例慢性乙肝、肝硬化患者血清TGF - β1,以抗体致敏的红细胞花环试验测定T淋巴细胞亚群。 1 慢性乙肝轻、中、重度及肝硬化患者血清TGF - β1水平明显高于对照组 ;2 慢性乙肝轻、中、重度、肝硬化患者血清CD3 + T细胞、CD4+ T细胞、CD4+ /CD8+ 明显低于对照组 ,CD8+ T细胞明显高于对照组。相关分析发现 ,血清TGF - β1与CD4+ T细胞、CD4+ /CD8+ 呈负相关 ,与CD8+ T细胞呈正相关。慢乙肝、肝硬化患者血清TGF -β1水平明显升高 ,而细胞免疫功能低下 ;TGF - β1对细胞免疫功能的抑制作用是慢性乙肝、肝硬化患者细胞免疫功能低下的原因之一Abstract: We observed the relationship between serum transforming growth factor-β1 (TGF-β1) and T lymphocyte subsets to search its role in cellular immune function. Serum TGF-β1 was detected by ELISA, meanwhile T lymphocyte subsets were detected. 1.Serum TGF-β1 levels in CHB and LC were notable higher than that in NC (P<0.01) and increased successively in mild, moderate, severe degree of CHB and LC. 2. CD 3 +T cells, CD 4 +T cells, CD 4 +/CD 8 + in CHB and LC were notable lower than those in NC and CD 8 +T cells were notable higher than that in NC. There was significantly negative correlation between TGF-β1 and CD 4 +T cells, CD 4 +/CD 8 + and positive correlation between TGF-β1 and CD 8 + T cells. Serum TGF-β1 levels in creased significantly in CHB and LC, but cellular immune function decreases. TGF-β1 may restrain cellular immune, this may be one of the causes of hypofunction of cellular immune in CHB and LC.
-
Key words:
- TGF-β1 /
- T lymphocyte subsets /
- cellular immune function
-
[1]中华医学会.病毒性肝炎防治方案[J].中华传染病杂志, 1995, 13 (4) ∶241-247. [2] DeBleserPJ, NikiT , RogiersV , etal.Transforminggrowthfactor-be tageneexpressioninnormalandfibroticratliver[J].JHepatol, 1997, 26 (4) ∶886-93. [3]刘芳, 刘金星, 李兵顺, 等.转化生长因子β1在慢性乙型肝炎患者肝细胞损伤和肝纤维化形成中的作用[J].中华传染病杂志, 1999, 19 (4) ∶241-244. [4]叶维法, 钟振义.肝炎学大典[M].天津:天津科学技术出版社.1996∶344. [5]毕爱华.医学免疫学[M].北京:人民军医出版社.1995∶78. [6] ItoN , Kawatas, TsushimaH , etal.Increasedcirculatingtransforminggrowthfactorbeta1inapatientwithgianthepatichemangioma:possiblecontributiontoanimpairedimmunefunction[J].Hepatology, 1997, 25 (1) ∶93-6. [7]刘丽霞, 张铮, 苏先狮, 等.慢性活动性乙型肝炎患者细胞免疫功能检测及临床意义[J].中国免疫学杂志, 1995, 11 (3) ∶176-178. [8]陈慰峰, 金伯泉.医学免疫学[M].第3版.北京:人民卫生出版社, 2001∶92.
本文二维码
计量
- 文章访问数: 2268
- HTML全文浏览量: 11
- PDF下载量: 741
- 被引次数: 0