Abstract: To explore the effect of percutaneous transhepatic cholangiography and drainage (PTCD) , percutaneous transhepatic insertion of biliary stents (PTIBS) and combined with continuously infusion arterial chemotherapeutics and chemotherapeutics embolization for treatment of malignant biliary obstruction. 35 patients with malignant obstructive jaundice were treated with PTIBS and after PTIBS 2weeks, performed 72 hours continuously local infusion arterial chemotherapeutics or chemotherapeutics embolization therapy, the period is 4-6 weeks. PTCD and PTIBS was all successful in our 35 cases, The total serum bilirubin decreased obviously, from (485±120) μmol/L before operation to (54±30) μmol/L two weeks after operation, and alkaline phosphatase and transaminase decreased obviously, too. The total eighty-five times continuously infusion arterial chemotherapeutics or chemotherapeutics embolization treatment was performed in 35 patients. All cases were followed up for 10～24 months. The survival rate of 6 and 12 monthes were 94.2% and 71.4%, respectively; The stents opened rate of 6 and 12 months were 85.7% and 74.2%, respectively. PTCD and PTIBS with combined continuously infusion arterial chemotherapeutics or chemotherapeutics embolization treatments are a safe and effective therapy for malignant biliary obstruction. They can also improve patients life quality and survival rate.