Abstract: To research the situation of hepatitis B and C viruses infection in tumor patients with transfusion history, we compared 493 tumor patients who have been ever transfused with 500 tumor patients who not transfused in our hospital. The results shown that two fold infection rate of hepatitis B and C viruses were 30.4% and 14.0%, double-fold was 9.5% in patients with transfusion history, which are significantly higher than those in the control group (17.8%, 3.8% and 2.8%, respectively, P<0.01) . We also found that there existed relationship between three infection types and transfusion quantity (P<0.01) . We could conclude that transfusion is a high-risk factor of hepatitis B and C viruses infection in tumor patients. It may be effective measures for decreasing infection by mastering transfusion sign, advocating volunteer donor and using high sensitivity screening.