PDF下载 ( 151 KB)
The factor analysis of accelerating liver function failure in the patients with human immunodeficiency virus and hepatitis C virus coinfection
-
摘要: 探讨HIV/HCV重叠感染患者肝脏功能进展的原因。回顾性比较HIV/HCV重叠感染患者和单独HCV感染患者两组的肝脏功能、病理情况、感染时间、免疫功能及综合分析HCVRNA定性检测与HCV抗体检测在两组中的异同。HIV/HCV重叠感染患者中肝功异常者占 5 8 5 % ,HCV感染组为 85 5 % ,肝功损伤程度亦较后者轻微 （P<0 0 5 ） ;两组患者在肝脏病理炎症活动和纤维化程度方面差异无显著性 （P =0 187,0 95 4 ） ;而重叠感染患者进展到肝功能异常的时间较单独HCV感染者提前 8年 （P <0 0 0 1） ;免疫功能方面 （CD+ 4 T、CD+ 8T）重叠感染者组与单独HCV感染者组比较 ,差异非常显著 （P <0 0 0 1;P <0 0 0 1） ;HCVRNA（+）同时HCV抗体 （+）的人数与HCVRNA（+）同时HCV抗体 （- ）的人数比较在重叠感染组为 5 2∶9例 ,在HCV感染组 4 4∶1例 ,两组间差异显著P =0 0 4 3。HIV/HCV重叠感染可加速丙型病毒性肝炎的进展 ,可能与HIV对...Abstract: To study the causes of accelerating liver function failure in the patients with HIV/HCV coinfection. The patients were divided into two groups, HIV/HCV coinfection group (n=82) and simple HCV infection group (n=62) . A retrospective study was designed to compare liver function, pathology of liver tissue, the time of infection, immune function, qualitative assay of HCV-RNA and HCV antibody between the two groups. Although there was significant difference between two groups on liver function (P<0.05) , but there were no significant differences in degree of inflammation of liver and degree of liver fibrosis in the two groups (P=0.187, 0.954) . However, the time when liver abnormality occurred in the patients with HIV/HCV coinfection was earlier 8 years than those with simple HCV infection (P<0.001) .There were significant differences between the two groups on the count of CD + 4T and CD + 8T (P<0.001, P<0.001) .Comparing the cases of HCVRNA (+) and anti-HCV (+) with the cases of HCVRNA (+) and anti-HCV (-) , we found that the ratio was 52 to 9 in the group of HIV/HCV coinfection, and 44 to 1 in the group of simple HCV infection. The difference was statistically significant between the two groups (P=0.043) . HIV/HCV coinfection can accelerate deterioration of hepatitis C, which maybe due to the effect of HIV on cellular immunity and humoral immunity.
-
Key words:
- HIV virus /
- Hepatitis C Virus /
- CD + 4T cell /
- HCV-RNA
-
[1]SorianoV , Garcia-SamaniegoJ .ImpactofchronicliverdiseaseduetohepatitisvirusesascauseofhospitaladmissionanddeathinHIV -infect eddrugusers[J].EurJEpidemiol, 1999, 15∶1-4. [2]病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19∶56-62. [3]ShermanK , RoustrerS , ChungR , etal.HepatitisC :prevalenceinHIV-infectedpatientsacrosssectionalanalysisoftheUSACTG[J].AntiviralTher, 2000, 5 (Suppl.1) ∶64-65. [4]HaganH , ThiedeH .Sharingofdrugpreparationequipmentasariskfac torforhepatitisC[J].AmJPublicHealth, 2001, 91∶42-46. [5]罗端德.传染病讲座[M].北京:人民卫生出版社, 2002∶114～122. [6]EysterME , DiamondstoneLS .NaturalhistoryofhepatitisCvirusinfec tioninmultitransfusedhemophiliacs:effectofcoinfectionwithhumanim munodeficiencyvirus.TheMulticenterHemophiliaCohortStudy[J].JAcquirImmuneDeficSyndr, 1993, 6 (6) ∶602-10. [7]MassimoPuoti, MaurizioBonacini.LiverFibrosisProgressionIsRelatedtoCD4CellDepletioninPatientsCoinfectedwithHepatitisCVirusandHumanImmunodeficiencyVirus[J].JInfectDis, 2001, 183∶134-137. [8]王克霞, 李朝品, 王建.丙肝患者PBMCMil-2R及T细胞亚群检测[J].吉首大学学报 (自然科学版) , 2001, 22 (4) ∶79-82. [9]CernyA , McHutchisonJG , PasquinelliC , etal.CytotoxicTlymphocyteresponsetohepatitisCvirus-derivedpeptidescontainingtheHLAA21bindingMoti[J].JClinInvest, 1995, 95∶521-530. [10]MullerHM , PfaffE , GoefferT , etal.PeripheralLeukocytesServeasaPossibleExtrahelaticSiteforHepatitisCvirusReplication[J].JGenVirol, 1993, 74 (4) ∶699-676. [11]王健, 张荣波, 许礼发, 等.HCV侵染患者外周血单个核细胞后对细胞免疫功能的影响[J].安徽医科大学学报, 1999, 34 (2) ∶103-105. -
本文二维码
计量
- 文章访问数: 2058
- HTML全文浏览量: 19
- PDF下载量: 762
- 被引次数: 0
下载:
