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Studies on relationship between pseudocholinesterase in serum and Child-Pugh classification in hepatic cirrhosis
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摘要: 为了研究血清拟胆碱酯酶 （PChE）活性与肝硬化Child -Pugh分级之间的关系 ,测定 6 4例肝硬化患者和5 0例健康人肝功能指标 （包括白蛋白 ,总胆红素 ）及血清PChE活性 ,并按Child分级进行比较。肝硬化组PChE活性较正常对照组显著降低 ,按Child分级 ,肝硬化组A级PChE活性与对照组 ,B级与A级 ,C级与B级之间差异均有显著性 （P <0 0 1） ,随Child分级而明显降低。因此 ,血清PChE活性可作为判断肝硬化严重程度的有效指标 ,对病情的诊断和预后判断有重要的指导意义。
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关键词:
- 拟胆碱酯酶 /
- 肝硬化 /
- Child-Pugh分级
Abstract: To study the relationship between the activity of serum pseudocholinesterase (PChE) and Child-Pugh classification in hepatic cirrhosis, 64 serum samples of patients with hepatic cirrhosis and 50 serum samples of the healthy were detected for hepatic functional indexes: serum albumin, total bilirubin and PChE, and the patients classified according to the Child-Pugh score were included in the study. The results showed that the activity of PChE remarkablely declined in hepatic cirrhotic patients. According to the Child-Pugh classification, the PChE in different groups varied obviously. Therefore, the activity of PChE in serum can be regarded as an effective marker to the extent of hepatic cirrhosis, which has the important guiding value on diagnosis and prognostic evaluation of hepatic cirrhosis.-
Key words:
- pseudocholinesterase /
- hepatic cirrhosis /
- Child-Pugh classification
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