Abstract: To study the efficacy on the treatment of hepatocellular carcinoma concomitant with hypersplenism using double embolization via hepatic and splenic arterialy. After a puncture via femoral artery, we catheterized into splenic arterialy and used gelfoam sponge as the embolic material for embolization, and then catheterized into hepatic arterialy for embolization, contrasted with the control group with a single TACE for the efficacy in principal aspects such as recovering liver and marrow reserve function, improving immunity of body, reducing tension of portal vein and so on. In test group which consists of 82 patients, blood corpuscles increased to some extent, PT and APTT improved notablely contrasted with the preoperative value, and blood platelet multipled from the former level after treatment; whereas in contrast group which consists of 86 patients PT and APTT prolonged, WBC and PLT decreased farther after treatment. There is no significant difference between two groups in liver function and kidney function, and the lesion of kidney function is not found. The laboratory examinations of immune function in the test group is remarkably greater than that of control group with significant difference. The tension of portal vein reduced obviously and UGIB has not taked place in test group, but there are 10 cases of UGIB in control group after TACE. The double embolization for the treatment of hepatocellular carcinoma concomitant with hypersplenism has presented curative effects on improving immunity of body and reducing tension of portal vein preferably, timesaving for whole treatment.