Abstract: To identified the risk factors for hospitalized patiens with cirrhosis developed renal dysfunction. By case control method, the clinic data of 221 patients were retrospective studied. In multivariate logistic regression analysis model, possible risk factors, including age, serum levels of album, prothrombin time, encephopathy, spontaneous bacterial peritonitis (SBP) , occurrence of esophageal varivceal bleeding, ascites, or treatment with i.v. aminoglycosids were identified. 27 patients developed renal dysfunction. Patients who developed renal dysfunction were more likely to have ascites (OR=12.68 95%CI=2.04-18.8) , SBP (OR=2.52, 95%CI=1.58-2.73) , treatment with i.v. aminoglycosids (OR=5.24 95% CI=2.78-15.4) , the score of Child-Pugh was Child C (OR=5.19 95% CI=4.02-6.8) . Ascite was an independent risk factor for development renal dysfunction for patients with cirrhosis.Ascites was an independent risk factor for development renal dysfunction for patients with cirrhosis.