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Study in relationship of helicobacter pylori infection and portal hypertensive gastropathy in patients with liver cirrhosis.
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摘要: 为了解门脉高压性胃病 (PHG)与幽门螺杆菌 (HP)的关系 ,采用尿素酶试验、血清HP抗体检测和14 C呼吸试验等方法检测 5 0例肝硬化PHG患者HP的感染率 ,并与非PHG肝硬化 (NPHG)、十二指肠球部溃疡 (DU)、功能性消化不良 (FD)三组患者比较。PHG组HP感染率为 36 % ,与NPHG组 (38% )、FD组 (4 4 % )分别比较差异无显著性 (P >0 0 5 ) ,与DU组 (94 % )比较差异有显著性 (P <0 0 1)。说明HP感染对PHG发病影响不大。Abstract: This study evaluates the relationship of Helicobacter pylori (H.pylori) infection and portal hypertensive gastropathy (PHG) in patients with liver cirrhosis. To detect H. pylori infectious rate by Urease test, 14 C urea breath test ( 14 C-UBT) and serological diagnostic test in 200 patients with portal hypertensive gastropathy (PHG) (50 cases) , liver cirrhosis (50 cases) , duodenal ulcer (50 cases) , and functional dyspepsia (50 cases) . Results showed H. pylori infectious rate was 36% (18/50) in patients with PHG and it is remarkably lower than that of patients with duodenal ulcer (94%) , but no clear difference in patients liver cirrhosis (38%) or functional dyspepsia (44%) . We consider that H. pylori infection seems to be unlikely in the pathogenesis of PHG.
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Key words:
- portal hpertension gastropathy /
- helicobacter pylori
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[1]ZulloA , RomitiA , RinaldiV , etal.Gastricepithelialcellproliferationinpatientswithlivercirrhosis[J].DigDisSci, 2001, 46 (3) ∶550～554. [2] BahnacyA , KupcsulikP , ElesZ , etal.Helicobacterpyloriinfectionincongestivegastropathy[J].Helicobacter, 1996, 1 (3) ∶168～171. [3] McCormackTT , SimsJ , Eyre-BrookⅠ, etal.Gastriclesionsinpor talhypertension:Inflammatorygastritisorcongestivegastropathy[J].Gut, 1985, 26 (2) ∶1226～1232. [4] 黄自平, 袁顺玉, 崔淑芬, 等.胃泌素和胃酸对门脉高压下胃粘膜的影响[J].中华消化杂志, 1989, 9 (3) ∶211～212. [5] LoWC , LinHJ, WangK , etal.GastricsecretioninChinesepatientswithcirrhosis[J].JClinGastroenterol, 1996, 23 (4) ∶256～260. -
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