Abstract: The variance of liver volume, spleen volume, the ratios of spleen to liver in liver cirrhosis were observed by CT measuring volumetry. So that laid a foundation of CT quantitative diagnosis for liver cirrhosis. The study included 100 subjects in total divided into 2 groups, the cirrhosis study group (50) and the normal control group (50) .All of 100 subjects had plain CT and/or enhanced CT scanning and clinical materials. The liver volume and the spleen volume of the means and standard deviations of liver group were (1068.3±201.7) cm 3 and (783.6±196.2) cm 3 respectively. The difference between the two means of liver volumes was significant statistically (P<0.0001) . The ratios of spleen to liver were (0.12±0.03) and (0.73±0.4) for the two groups respectively. The difference between the two ratio was significant in statistics (P<0.0001) . By one-way analysis of variance it showed that, the liver volume decreased as Child-Pugh grade increased, and the ratio of spleen to liver volume increased as Child-Pugh grade increased. liver volumetry may be one of important indices available for quantitative diagnosis of liver cirrhosis.