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Detection and significance of plasma procalcitonin and soluble intercellular adhesion molecule-1 in patients with liver cirrhosis
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摘要: 观察肝硬化患者血浆降钙素原 （PCT）、可溶性细胞间粘附分子 - 1（sICAM - 1）水平变化及其各自临床意义。采用免疫发光法及ELISA法检测 78例肝硬化患者及 30例正常对照者血浆PCT、sICAM - 1水平。肝硬化患者血浆PCT、sICAM - 1水平显著高于正常对照组 ,失代偿期显著高于代偿期 （均P <0 0 1） ,随Child分级的增加 ,血浆PCT、sICAM - 1水平逐渐升高。肝硬化患者血浆PCT水平与血清TBil水平呈正相关 ,与PTa呈负相关 ,与血清ALT水平无明显相关性 ;血浆sICAM - 1水平与血清TBil、ALT水平呈正相关 ,与PTa呈负相关。二者血浆水平可反映肝细胞损伤程度。
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关键词:
- 肝硬化 /
- 降钙素原 /
- 可溶性细胞间粘附分子-1
Abstract: To observe the changes of plasma procalcitonin (PCT) , soluble intercellular adhesion molcule-1 (sICAM-1) levels in patients with liver cirrhosis (LC) and their clinical significance. Plasma PCT and sICAM-1 levels in 78 LC patients and in 30 normal controls (NC) were measured by immunoluminometric assay and ELISA, respectively. Plasma PCT?sICAM-1 levels of LC were significantly higher than those in NC, higher in decompensated phase than those in compensated phase (P<0.01) and with positive relationship. Plasma PCT?sICAM-1 levels increased gradually in pace with the progression of Child grading. Plasma PCT levels positively correlated with serum TBil levels, negatively correlated with PTa. Plasma sICAM-1 levels positively correlated with serum TBil and ALT levels, and negatively correlated with PTa. Plasma PCT sICAM-1 levels can reflect the degree of hepatocellular injury. -
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