HIV/HCV重叠感染患者病情进展的相关因素研究

张永宏; 陈新月; 吴昊; 张彤; 张可; 徐莲芝

HIV/HCV重叠感染患者病情进展的相关因素研究

基金项目:

国家十五科技攻关资助项目 ,课题号 2 0 0 1BA70 5B0 1；

详细信息

中图分类号: R512.6
计量
- 文章访问数: 2396
- HTML全文浏览量: 32
- PDF下载量: 829
- 被引次数: 0
出版历程
- 出版日期: 2004-01-20

Associated factors of disease progression in HIV/HCV co-infection

Research funding:

摘要

摘要: 探讨HIV/HCV重叠感染患者病情进展的原因和影响预后的相关因素。选择HIV/HCV重叠感染患者这一特定人群 ,按照疾病进展分成艾滋病组（AIDS）和HIV感染组（freeofAIDS） ,回顾性分析两组间免疫功能、HIV病毒载量、肝脏功能的差异 ,探讨可能影响病情进展的相关因素。艾滋病组与HIV感染组比较 :艾滋病组患者的细胞免疫功能（CD+ 4 T、CD+ 8T）均低于HIV感染组 ,差异非常显著（P <0 0 0 1;P =0 0 0 3） ;HIV病毒载量在艾滋病组明显高于HIV感染组 ,差异显著（P =0 0 0 5 ） ;艾滋病组的肝脏功能（ALT、AST）明显高于HIV感染组（P值分别为 0 0 4 3、0 0 0 2 ） ;蛋白合成指标（TP、ALB）艾滋病组较HIV感染组低下 ,差异非常显著（P <0 0 0 1）。以Logistic回归分析 ,CD+ 4 T、感染时间和ALB是预测疾病进展的独立危险因素（P <0 0 0 1）。回归方程预测准确率为 97 0 %。HIV/HCV重叠感染可加快病情进展 ,ALB与CD...
- 人免疫缺陷病毒 /
- 丙型肝炎病毒 /
- 获得性免疫缺陷综合征 /
- CD+4细胞 /
- 白蛋白
Abstract: To discuss the reason of disease progression in HIV/HCV co-infected patients. Retrospective study was designed to analysis the immunological function, HIV-RNA Viralload liver function and prognosis in HIV/HCV co-infected patients. According to the disease progression, the patients are divided into two groups: AIDS group and free of AIDS group. The difference of immunological function, liver function in groups was performed statistics analysis. Immunological function (CD + 4T, CD + 8T) are lower in AIDS group than in free of AIDS group (P<0.001;P=0.003) , HIV-RNA viral load is higher in AIDS group than in free of AIDS group (P=0.005) . In the aspect of liver function alanine and aspartate aminotramsferase (ALT, AST) are higher in AIDS group than in free of AIDS group (P=0.043;P=0.002) . Total protein (TP) and albumin (ALB) are lower in AIDS group than in free of AIDS group (P<0.001) . Logistic analysis predicts that CD + 4T, duration of HCV infection and ALB are independent risk factors (P<0.001) . Predicted percentage of correct is 97.0%. HIV/HCV co-infection effect each other, increasing the disease progression. Albumin, CD + 4T cell and duration of HCV infection are independent risk factors of AIDS progression.
- human immunodeficiency virus /
- Hepatitis C virus /
- Acquired immunodeficiency syndrome /
- CD + 4T cell /
- Albumin

HTML全文

参考文献(9)

[1] ShermanK , RoustrerS , ChungR , etal.HepatitisC :prevalenceinHIV-infectedpatientsacrosssectionalanalysisoftheUSACTG[J].AntiviralTher, 2000, 5 (Suppl.1) ∶64-65.

[2] HaganH , ThiedeH .Sharingofdrugpreparationequipmentasariskfac torforhepatitis[J].CAmJPublicHealth, 2001, 91∶42-46.

[3]SorianoV , Garcia-SamaniegoJ .ImpactofchronicliverdiseaseduetohepatitisvirusesascauseofhospitaladmissionanddeathinHIV -infect eddrugusers[J].EurJEpidemiol, 1999, 15∶1-4.

[4] 病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19∶56-62.

[5] EricSRosenberg, JamesMBillingsley.VigorousHIV -1-SpecificCD4+TCellResponsesAssociatedwithControlofViremia[J].Science, 1997, 278∶1447-1450.

[6] Martinez-SierraC , ArizcorretaA .ProgressionofchronichepatitisCtoliverfibrosisandcirrhosisinpatientscoinfectedwithhepatitisCvirusandhumanimmunodeficiencyvirus[J].ClinInfectDis, 2003, 36 (4) ∶491-8.

[7] EysterME , DiamondstoneLS .NaturalhistoryofhepatitisCvirusinfec tioninmultitransfusedhemophiliacs:effectofcoinfectionwithhumanim munodeficiencyvirus.TheMulticenterHemophiliaCohortStudy[J].JAcquirImmuneDeficSyndr, 1993, 6 (6) ∶602-10.

[8] MassimoPuoti, MaurizioBonacini.LiverFibrosisProgressionIsRelatedtoCD4CellDepletioninPatientsCoinfectedwithHepatitisCVirusandHumanImmunodeficiencyVirus[J].JInfectDis, 2001, 183∶134～137.

[9] DaarES , LynnH , DonfieldS , etal.HepatitisCvirusloadisassociatedwithhumanimmunodeficiencyvirustype1diseaseprogressioninhemophiliacs[J].JInfectDis, 2001, 183∶589-95.

施引文献

资源附件(0)

访问统计