TAP和HLA-Ⅰ类抗原在人肝细胞癌中的表达

陈玮; 邓小玲; 蔡美英; 魏大鹏

TAP和HLA-Ⅰ类抗原在人肝细胞癌中的表达

基金项目:

国家自然科学基金资助项目 (批准号 30 0 70 85 5 )；

详细信息

中图分类号: R735.7
计量
- 文章访问数: 2172
- HTML全文浏览量: 14
- PDF下载量: 888
- 被引次数: 0
出版历程
- 出版日期: 2003-03-20

Expression of TAP and HLA-Ⅰ antigens in hepatocellular carcinoma

Research funding:

摘要

摘要: 为探明肝细胞癌（HCC）组织中抗原Ⅰ类递呈途径的存在状况 ,采用免疫组织化学技术对 3 0例HCC和2 8例癌旁组织中TAP与HLA -Ⅰ类抗原的表达进行了检测。结果显示 ,HCC和癌旁组织基本上都有较强的TAP和HLA -Ⅰ类抗原的表达 ,两者无明显差异（x2 <0 0 2 ,P >0 0 5 ） ,这表明HCC中抗原Ⅰ类递呈途径可能基本正常 ,胞毒性T细胞（CTL）能够杀伤HCC细胞 ,这就为针对HCC的CTL表位肽疫苗的设计和构建提供了实验研究基础
- 肝细胞癌 /
- HLA-Ⅰ类抗原 /
- TAP /
- 免疫组织化学
Abstract: To determine the functional state of class Ⅰ presenting pathway for antigens in hepatocellular carcinoma (HCC) , the expression of TAP and HLA-Ⅰ antigens were detected in 30 cases of HCC and 28 cases of tissues-surrounding tumor by immunohistochemistry. The results showed most HCC and tissues-surrounding tumor tested had strong expression of TAP and HLA-Ⅰ antigens, there was no statistical difference between them (x 2<0.02, P>0.05) . It was suggested that there could be a functional class Ⅰ presenting pathway for antigens in HCC. These make it possible that cytotoxic T cells can kill the HCC cells, and provide experimental basis for design for HCC CTL eptope peptide vaccine.
- hepatocellular carcinoma /
- TAP /
- HLA-Ⅰ antigens /
- immunohistochemistry

HTML全文

参考文献(7)

[1]MeliefCJM , KastWM .LessonsfromTcellresponsestovirus-inducedtumorsforcancereradicationingeneral[J].CancerSurv, 1992, 13∶81-89.

[2]Ruiz-CabelloF , GarridoF .HLAandcancer:fromresearchtoclinicalimpact[J].ImmunolToday, 1998, 19 (12) ∶539-542.

[3]CrommeFV , AireyJ, etal.Lossoftransporterprotein, encodedbytheTAP -1gene, ishighlycorrelatedwithlossofHLAexpressionincervicalcarcinomas[J].JExpMed, 1994, 179∶335-340.

[4]SungCH , HuCP , etal.ExpressionofclassⅠandclassⅡmajorhisto compatibilityantigensonhumanhepatocellularcarcinoma[J].JClinIn vest, 1989, 83 (2) ∶421-427.

[5]WadeeAA , PatersonA , etal.HLAexpressioninhepatocellularcarcino malines[J].ClinExpImmunol, 1994, 97 (2) ∶328-33.

[6]KurokohchiK , CarringtonM , etal.ExpressionofHLAclassⅠmoleculesandthetransporterassociatedwithantigenprocessinginhepato cellularcarcinoma[J].Hepatology, 1996, 23 (5) ∶1181-1188.

[7]ButterfieldLH , MengWS , etal.TcellresponsestoHLA -A 0201-restrictedpeptidesderivedfromhumanαfetoprotein[J].JImmunology, 2001, 166∶5300-5308.

施引文献

资源附件(0)

访问统计