死胎大脑组织中HBVDNA表达的临床和病理研究

刘伟; 赵伟; 罗婵; 刘兰侠; 王兰

死胎大脑组织中HBVDNA表达的临床和病理研究

基金项目:

铁道部 2 0 0 0年自然科技资金资助(J2 0 0 0Z0 95 )；

详细信息

中图分类号: R446.8
计量
- 文章访问数: 1993
- HTML全文浏览量: 10
- PDF下载量: 671
- 被引次数: 0
出版历程
- 出版日期: 2002-06-20

The clinical and pathological study on the expression of HBVDNA in the cerebral tissues of the died fetus that the puerperal delivery with hepatitis virus B.

Research funding:

摘要

摘要: 观察死胎大脑组织中HBVDNA表达的情况 ,探讨通过产妇传播到死胎大脑组织中的HBV是否存在复制。采集 4 0例乙型肝炎产妇产下的死胎 ,常规尸检 ,取大脑组织。采用原位分子杂交法 ,检测其中的HBVDNA ;回顾产妇产前静脉血HBV的检测结果。死胎大脑组织中HBVDNA的检出率为 13/ 4 0 (33% )例。产妇产前静脉血HBV呈高、低和无复制状态时 ,大脑组织中HBVDNA的检出率分别为 1/ 4 (2 5 % )例、5 / 2 0 (2 5 % )例和 7/ 16 (44 % )例 ;三者之间相互比较 ,差异不显著 (P >0 0 5 )。HBVDNA颗粒在大脑胶质细胞浆、血管中呈点、灶状分布 ,大脑胶质细胞核不着色。死胎大脑组织中有HBV复制 ;死胎大脑组织中HBVDNA表达与产妇血清中HBV复制状态无关
- 死胎 /
- 大脑组织 /
- 原位分子杂交 /
- 乙型肝炎病毒脱氧核糖核酸
Abstract: To observe the expression of HBVDNA and whether there were copy of HBV in the cerebral tissues of the died fetus that the puerperal delivery with hepatitis virus B. 40 cases such died fetus collected were made the autopsy for cerebral tissues and detected HBVDNA with in situ molecule hybridization technique. Investigated the detection on HBV in the mother veins before delivery. For the cerebral tissues, there were 13 (33%) cases detected out HBVDNA. When the HBV was high, low and without replication status, it was 1/4 (25%) cases, 5/20 (25%) cases and 7/16 (44%) cases for the rate of HBVDNA in the cerebral tissues. For the rate of HBVDNA, it was not statistically significant for the differences among the high and low, without replication status ( P>0 05) . HBVDNA were mainly on the surface of the cerebral vessel and in the plasma of the astrocyte, but were not in the astrocyte nuclei. There were HBV replication in the cerebral tissues of the died fetus, but it was not related to the HBV replication status in the pregnant woman veins for expression of HBVDNA in the cerebral tissues of the died fetus.
- Died fetus /
- HBVDNA /
- Cerebral tissues /
- In situ molecule hybridization technique

HTML全文

参考文献(7)

[1] 赵若惠, 何南祥, 袁冬生, 等.乙型肝炎产妇传播的研究[J].中华流行病学杂志, 1984, 12 (1) ∶16-18.

[2] 朱启熔, 段恕诚, 徐华芳, 等.乙型肝炎病毒从母亲到婴儿的产前传播[J].中华传染病学杂志, 1989, 10 (7) ∶159-161.

[3]成令忠, 主编.组织学与胚胎学[M].北京:人民卫生出版社, 第三版, 1991.98-103.

[4]马晓丽, 孙海基, 黄海士, 等.济南地区乙型肝炎病毒母婴传播途径的探讨[J].中国优生与遗传杂志, 1999, 7 (5) ∶67.

[5]AbbottWG , GeursenA , FraserJD , etal.TheinfluenceofamaternalchronichepatitisBvirusinfectionontherepertoireoftranscribedT -cellreceptorbetachainvariableregiongenesinhumancordblood[J].Hepa tology, 1995, 22 (4Pt1) ∶1034-9.

[6]王珊珊, 姜普林, 彭桂福, 等.乙型肝炎病毒的父儿传播与大脑外定位[J].中华大脑脏病杂志, 1999, 7 (4) ∶203-206.

[7]赵淑华, 韩丽英, 张立会, 等.乙型肝炎病毒携带者妊娠对母婴的危害及预防措施的研究[J].白求恩医科大学学报, 2000, 26 (1) ∶75-76.

施引文献

资源附件(0)

访问统计