血清丙氨酸氨基肽酶(AAP)测定在诊断肝胆疾病中的应用

涂向东; 陈敏; 朱忠勇; 胡望平

血清丙氨酸氨基肽酶(AAP)测定在诊断肝胆疾病中的应用

详细信息

中图分类号: R446.11
计量
- 文章访问数: 2293
- HTML全文浏览量: 13
- PDF下载量: 853
- 被引次数: 0
出版历程
- 出版日期: 2002-06-20

Application of determination of serum Alanine Aminopeptidase to diagnosis of liver and biliary tract diseases

摘要

摘要: 为观察血清丙氨酸氨基肽酶（AAP）水平对肝胆疾病的临床诊断价值。用自动分析仪速率法测定 2 2 9名肝胆疾病患者和 70名健康人血清AAP活力。结果显示肝癌、各类肝炎、胆道阻塞病人血清AAP活力明显高于健康对照组（P <0 0 1） ,且与γ -谷氨酰转肽酶（γ -GT）、碱性磷酸酶（ALP）活力呈正相关 ;与血清总胆红素（T -Bil）、丙氨酸转氨酶（ALT）不存在明显相关性。结论 :在肝胆疾病诊断中 ,AAP较其它肝功能指标更具灵敏的特异性指标
- 丙氨酸氨基肽酶 /
- 肝胆疾病
Abstract: To study the diagnostic value of serum alanine aminopeptidase (AAP) activity in both liver and biliary tract diseases. An automated assay was used to analyse serum AAP activities of 229 patients with hepatobiliary diseases and 70 normal individuals. The serum AAP levels of patients with liver cancer, chronic hapatitis and biliary obstruction were significantly higher than that of normal controls ( P<0 01) . There were positive correlation between serum AAP level and that of γ-GT?ALP and had no correlation with the T-Bil, ALT. The specifity of AAP for the diagnosis of hepatobiliary diseases was better than that of other indicator. Serum AAP is a sensitive and specific indicator for diagnosis of hepatobiliary diseases.
- Alanine aminopeptidase /
- Hepatobiliary disease

HTML全文

参考文献(8)

[1]Mueller PW, Phillips DL, Steinberg KK. Alanine aminopeptidase in Serum: automated optimized assay, and effects of age, sex, smoking, and alcohol consumption in a selected population[J]. Clin Chem, 1987, 33∶363-366.

[2]Favaloro EJ, Browning T, Nandurkar H. The hepatobiliary disease marker serum alanine aminopeptidase predominantly comprises an isoform of the haematological myeloid differentiation antigen and leukaemia marker CD-13/gp150[J].Clin Chim Acta, 1993, 81-90.

[3]Look AT, Ashmun RA, Shapiro LH, et al. Human myeloid plasma membrane glycoprotein CD-13 (gp150) is identical to aminopeptidase N[J]. J Clin Invest, 1989, 83∶1299-1307.

[4]Sanderink G, Artur Y, Schlete F, et al. Alanine aminopeptidase in serum:biological variations and reference limits[J]. Clin Chem, 1988, 34∶1422-1426.

[5]Sidorowicz W, Hsia W, Maslej-Zownir 0, et al. Multiple molecular forms of human alanine aminopeptidase:immunochemical properties[J].Clin Chim Acta, 1980, 107∶245-256.

[6]Bradstock KF, Favaloro EJ, Kabral A, et al. Myeloid progenitor surface antigen identified by monoclonal antibody[J].British Journal of Haematology, 1985, 61∶11-20.

[7]Sanderink G, Artur Y, Paille F et al. Clinical significance of a new isoform of serum alanine aminopeptidase; relationship with liver disease and alcohol consumption[J].Clin Chem Acta, 1989, 179∶23-32.

[8]Sanderink G, Artur Y, siest G. Human aminopeptidases: a review of the literature[J].Clin Chem Clin biochem, 1988, 26∶795-807.

施引文献

资源附件(0)

访问统计