Abstract: To research the clinical diagnosis standard, type of pathogens and antibiotics resistance in chronic hepatopathy patients with SBP. The clinical data and drug resistancce of 40 chronic hepatopathy with SBP, which had positive ascites culture results, were analyzed. ① The clinical symptoms, signs and laboratory findings are atypical. ② The percentage of pathogens is as the following disease-producing pathogen accounts for 17 5%, opportanistic pathogen 82 5%. Gram-positive bacillis occupies 47 5%. Gram-negative bacillis occupies 52 5%. The predominant strain is E. coli (35%) . ③Rifampicinum, cefotaxime, ceftriaxone, cefradine and agtreonam are rarely drug-resistant. The risistance to Quinolone kind and piperacillin increse significantly (30-47 5%) . The induction of β-lactamase inhibitor nearly doubles the sesitivity to β-lactams. ④MRSA and MRSE are highly sensitive to demetlyl-vancomycine. Most of staphylococcus in still sesentive to the generation cephalosporines and aminoglycosides. To use antibiotics more reasonably, the resistance of bacteria should be closely monitored, vancomycine should not be abused if the pathogen is not MRSA or MRSE.