Abstract: To analyse mutiple risk factors of predictive survive of severe types virous hepatitis, and to make a scored system which could be determined patient's prognosis. One hundred seventy patients at the end of hospitalization were divided into alive group (n=45) and dead group (n=125) . 133 patients were men, and 37 patients were women. The average age was 43 5 years old (range from 8 to 78) . Twenty clinical and laboratory parameters were investigated as predictive risk factors. Univariate analysis was first made. Variables reaching statistical significance ( P <0 05) were subsequently introduced in logistic regression to identify the independent risk factors for patient's survive. The methods of statistical analysis were performed with SPSS 6 0 for WINDOWS statistical package. Nine clinical and laboratory parameters, PTA, serum , hepatic encephalopathy, clinical types of serious virous hepatitis, GI bleeding, hepatic kinedy sydrome, total bilirubin serum BUN, and ascites were closely related to prognosis of severe type of virous hepatitis by analysis of univariate. Four independent risk factors, PTA, serum , hepatic encephalopathy, and clinical types of serious virous hepatitis were obtained by Logistic regression. A scored system was made accroding to those 4 parameters. The threshold score of death was 5. The coincidence rate was 80% by retrospective study of 170 patients with serious virous hepatitis. PTA, serium , hepatic encephalopathy, and clinical types of serious virous hepatitis are independent predictive factors in patients with serious virous hepatitis. It is important that the risk factors should be early assessed, ward off, and treated. The treatment strategy can be determined and the medical resources can be reasonably used according to this score system.