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Five years follow-up observation on the benignant hepatism patients of AFP rise.
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摘要: 探讨AFP升高的良性肝病患者原发性肝癌发生率。对AFP升高的 16 4例良性肝病患者追踪随访 5年 ,每 3个月一次检测AFP、肝功能、B超等。 8例急性肝炎及 6例重型肝炎均无恶变 ,而肝硬化恶变为 14 6 % (7/48) ,明显较慢性肝炎 3 9% (4/10 2 )高 (P <0 0 5 ) ,AFP动态观察中 ,一过升高型、反复波动型、持续低浓度型、稳定上升型发生恶变分别为 0 % (0 /36 )、4 2 % (1/2 4 )、6 9% (7/10 1)、10 0 % (3/3)。对AFP升高的慢性肝病患者 3个月一次的追踪随访 ,可早期发现原发性肝癌。Abstract: To study the occurrence of primary liver cancer (PLC) among benignant hepatism patients with AFP rise. A total of 164 persons, who were benignant hepatism patients with AFP rise, were checked up by serum AFP, liver function test and ultrasound B every 3 months, and they were follow-up for 5 years. During 5 years follow-up, none of acute hepatitis and severe hepatitis turned into PLC, while 14 6% (7/48) and 3 9% (4/102) patients respectively in liver cirrhosis and chronic hepatitis turned into PLC ( P <0 05) . At the follow up of AFP, the occurrence of PLC among once rise group, recurrent fluctuating group, continuous lowgrade rise group and stable rise group were 0% (0/36) ?4 2% (1/24) ?6 9% (7/101) and 100% (3/3) respectively. The results indicated that followed up every 3 months in chronic hepatism patients of AFP rise can make early diagnosis of PLC.
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Key words:
- Hepatocellular Carcinoma /
- AFP /
- Diagnosis
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