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Erythrocyte deformability and the energy metabolism of erythrocyte in patients with hepatic cirrhosis
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摘要: 观察肝硬化患者红细胞变形性 （ED）、红细胞能量代谢和血氧变化。以红细胞ATP和 2 3-二磷酸甘油酸 （2 3-DPG）含量作为衡量红细胞能量代谢状态的指标 ,对 32例肝硬化患者取血动态观察其ED、ATP和 2 3-DPG含量、PaO2 和SaO2 的变化并与正常人比较。肝硬化患者的ED、PaO2 和SaO2 明显降低 ,2 3-DPG含量明显增高 ;并发肝性脑病 （HE）时PaO2 明显降低 ,ATP及 2 3-DPG含量明显减少。肝硬化患者的ED明显降低并伴有低氧血症 ;红细胞能量代谢降低与HE的发生有关。
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关键词:
- 肝硬化 /
- 红细胞变形性 /
- ATP /
- 2.3-二磷酸甘油酸 /
- 肝性脑病
Abstract: To observe the changes of erythrocyte deformability (ED) , the energy metabolism of erythrocyte and arterial blood gas in patients with hepatic cirrhosis. ED, the intracellular levels of ATP and 2 3-diphosphoglyceric acid (2 3-DPG) of erythrocyte, PaO 2 and SaO 2 were dynamically observed in 32 patients. ED, PaO 2 and SaO 2 were markedly lower than that of controls, the level of 2 3-DPG in patients was significantly higher than that of controls; The levels of ATP and 2 3-DPG in patients complicated with hepatic encephalopathy (HE) decreased evidently. There are decrease of ED and hypoxemia in patients with hepatic cirrhosis; The decrease of the energy metabolism of erythrocyte in patients complicated with HE may be related to the occurrence of HE. -
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