Abstract: To observe the levels of High-density lipoprotein cholesterol and apolipoprotein A 1, B 100 in serum of liver complaint and to explore their role in development of liver complaint. The levels of HDL-C?apoA 1?apoB 100 in serum of liver complaint were detected by using enzyme analysis and immune turbidimetric analysis. The levels of HDL-C?apoA 1 in serum of liver complaint were obviously lower than that of control group. Especially in grade both B and C hepatocirrhosis and hepatitis gravis. The levels of apoB 100 in serum of hepatocirrhosis and hepatitis gravis were obviously lower than that of control group, but the level of apoB 100 in serum of acute hepatitis, chronic hepatitis and the liver of cancer raised slightly or approached to normal. HDL-C?apoA 1?apoB 100 are very important in pathogenesis and evolution of liver complaint; their levels are closely related with degree of the liver damage.