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Analysis of the Relationship and Clinical Sense among HBeAg, HBV-DNA and Pre-S1 antigen
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摘要: 了解HBeAg、HBV -DNA及前S1抗原相关性及其临床意义。采用ELISA法检测HBV标志物 ,PCR法检测HBV -DNA。 196例不同模式HBV感染者血清HBV -DNA及前S1抗原的总检出率分别为 38 78%和4 0 30 % ,二者无明显差异 （P >0 0 5 ）。其中 4 4例HBeAg阳性模式感染者HBV -DNA和前S1抗原的检出率分别为 88 6 4 %和 86 36 % ,两者无明显差异 （P >0 0 5 ）。 15 2例不同模式HBeAg阴性感染者HBV -DNA和前S1抗原的检出率分别为 2 4 34%和 2 6 97% ,明显低于HBeAg阳性模式的检出率 ,二者有显著性差异 （P <0 0 5 ）。结论 :HBeAg、HBV -DNA及前S1抗原间有着密切的相关性。前S1抗原是病毒复制的又一新标志 ,且与病程的发展及疗效的观察有着重要的意义。
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关键词:
- HBeAg /
- HBV-DNA /
- 前S1抗原聚合酶链反应 /
- 酶联免疫吸附试验
Abstract: To investigate analysis of the relationship and clinical sense among HBeAg?HBV-DNA and pre-S 1 antigen, They were detected by PCR and EL1SA. The total detection rate of HBV-DNA and Pre-S 1antigen in 196 cases with different mould were 38 78% (76/196) and 40 30% 79/ 196) . The detection rate of HBV-DNA and Pre-S 1 antigen in 44 Cases HBeAg Positive Patients were 88 64% (39/44) and 86 36% (38/44) . The detecfion rate of HBV-DNA and Pre-S 1 anfigen in 152 cases HBeag negative patients were 24 34% (37/152) and 26 97% (41/152) . There was a close relationship among HBeAg?HBV-DNA and Pre-S 1 antigen.-
Key words:
- HBeAg /
- HBV-DNA /
- Pre-S 1 antigen /
- PCR
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[1] 柳长柏, 费国农, 姚光弼, 等乙型肝炎病毒感染者血清前S1和前S2抗原同步检测的临床意义[J].上海医学, 1997, 14 (11) ∶631 [2]冯福民, 朱志宝, 张习坦, 等乙肝病毒前S1抗原检测方法及其临床意义探讨[J].天津医学, 1998, 26 (2) ∶74 -
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