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The effect of Kangxianruanjian on TGF β1 and it's the recepters in liver fibrosis in rats
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摘要: 观察抗纤软坚冲剂对转化生长因子 β1及其受体的影响。采用四氯化碳和小牛血清白蛋白建立大鼠肝纤维化模型 ,通过病理细胞学、免疫组化及图像分析等方法 ,证明抗纤软坚冲剂能明显抑制肝纤维化大鼠的肝星状细胞与转化生长因子 β1及其受体。其机理可能是通过抑制肝星状细胞的活化进而减少了转化生长因子 β1及其受体的表达。
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关键词:
- 抗纤软坚冲剂 /
- 肝纤维化 /
- 转化生长因子β1 /
- 转化生长因子β1受体
Abstract: To investigate the effect on TGF β1 and the receptors of TGF β1 controlled by KANGXIANRUANJIAN and the effect on anti-fibrosis with the theory. As an animal experiment, a fibrosis model of rats with carbon tetrachloride and bovine serum albumin was made. The effect on anti-fibrosis was determined by pathologic cytology, immune histochemistry and image analysis. KANGXIANRUANJIAN could inhibit HSCs, TGF β1 and the receptors of TGF β1 in the fibrosis model of rats. KANGXIANRUANJIAN could affect in the fibrosis model of rats. The reason may be that the activity of HSCs is inhibited so that TGF β1 and the receptors of TGF β1 are decreased.-
Key words:
- KANGXIANRUANJIAN /
- the fibrosis of liver TGβ1 /
- receptors of TGF β1 /
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[1] 苑淑芳, 张俊富, 崔丽安, 等抗纤软坚冲剂抗肝纤维化临床研究[J]中西医结合肝病杂志, 1999, 9 (4) ∶33-34 [2] 张俊富, 苑淑芳, 崔丽安, 等抗纤软坚冲剂抗肝纤维化实验研究[J]上海中医药杂志, 2001, (待发表) [3]罗瑞红, 杨绍基转化生长因子β1与肝纤维化[J]国外医学内科学分册, 2000, 27 (8) ∶348-350 [4]谭龙益, 王皓, 孔宪涛HBV基因组表达对TGFβ及其Ⅱ, Ⅲ型受体的转录调控[J]中华消化杂志, 1998, 18 (2) ∶125-126. -
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