Abstract: For researching differentia of the diffuse liver cancer from portal cirrhosis with ultrasound, the sonograhpic images of 15 patients with diffuse liver cancer and 30 patients with portal cirrhosis (were comparely analysed) In the patients with diffuse liver cancer, the liver enlarge uauslly and the echo of nodule is more obvious, the rate of portal embolism and swelling of lymph nodes in hepatic porta is higher In the patients with portal cirrhosis, the liver contract usually and the echo of proliferation of fiber is obvious, the rate of spleen enlargement and sacites is higher and the degree is more serious, and the rate of gallbladder edematous is higher It is valuable for differentiating the diffuse liver cancer from portal cirrhosis to observe sonographic characteristic of inside and outsider of liver