PDF下载 ( 82 KB)
The study of the effection on the patients suffered form hepatocellular carcinoma (HCC) by the hepatitis G virus (HGV) infection
-
摘要: 探讨庚型肝炎病毒 （HGV）感染在原发性肝细胞癌 （HCC）发生中的作用。采用RT -PCR法及ELISA法对实验组 （77例HCC患者 ） ,对照 1组 （5 6例健康体检者 ）及对照 2组 （38例慢肝肝硬化病人 ）分别进行HGVRNA、抗 -HGV和抗 -HCV测定。对随机抽取的实验组 5 8例 ,对照 1组 38例和对照 2组 30例的HGVRNA检测 ,分别查到阳性 3例、2例和 2例。三组间P值均 >0 0 5 ,无显著性差异。三组抗 -HGV检出率分别为 2 5 9%（2 0 / 77） ,7 2 % （4/ 5 6 ）和 8 3 % （3/ 36 ） ,实验组与对照 1组P <0 0 1,实验组与对照 2组间P <0 0 5。三组间抗 -HCV检出率分别为 18 1% （14/ 77） ,1 7% （1/ 5 6 ）和 2 8% （1/ 36 ） ,2 7例抗 -HGV阳性者中抗 -HCV阳性 12例 ,重叠率 44 4% ,16例抗 -HCV阳性中 11例抗 -HGV阳性 ,重叠率 6 8 7%。结论HGVRNA感染对HCC的发生未见明显...
-
关键词:
- 庚型肝炎病毒(HGV) /
- 原发性肝细胞癌(HCC)
Abstract: To study the effection on the patients suffered from hepatocellular carcinoma (HCC) by the hepatitis G virus (HGV) infection, Serum HGVRNA (NS3) , anti-HGV and anti-HCV were detected by RT-PCR or ELISA in experiment group (77patients with HCC) , control group1 (56 persons with health checking annual) and control group2 (38 patients with liver cirrhosis after hepatitis ) . The Positive rate of HGVRNA was 5 2% (3/58) in experiment group, 5 3% (2/38) in control group1 and 6 7% (2/30) in control group2. P>0 05. The positive rate of anti-HGV and anti-HCV in three groupswere 25 9% (20/77) , 7 2% (4/56) and 8 3% (3/36) , P<0 01;18.1% (14/77) , 1.7% (1/56) and 2.8% (1/36) , P<0.01. The anti-HCV was detected in 12 of 27 patients with anti-HGV positive, the co-positive rate was 44.4%; while the anti-HGV was detected in 11 of 16 patients with anti-HCV positive, the co-positive rate was 68.7%. No effection have been found on the HCC by HGV infection. Anti-HCV may disturb the anti-HGV when the later is being detected by ELISA.-
Key words:
- Hepatitis G virus /
- Hepatocellular carcinoma
-
[1]AlterHJ, NakatsujiY , MelpolderJ , etal.TheIncidenceoftrans fusionassociatedhepatitisGvirusinfectionanditsrelationtoliverdisease[J]NEnglJMed, 1997, 336∶747. [2]AlterMJ , GallagherM , MorrisTT , etal.Acutenon-A -Ehep atitisintheUnitedStatesandtheroleofhepatitisGvirusinfection[J]NEnglJMed, 1997, 336∶741. [3]CotlerSJ, GretchDR , BronnerMP , etal.HepatitisGvirusco-in fectiondoesnotalterthecourseofrecurrenthepatitisGvirusinfec tioninlivertransplantationrecipients[J]Hepatology, 1997, 26∶432. [4]乐美兆, 鞠九龙, 等庚型病毒性肝炎动物模型—恒河猴肝的超微结构及免疫组织化学研究[J]中华传染病杂志, 2000, 18 (1) 54 [5]许德军单纯HGV感染急性肝炎患者的临床与病理研究[J]胃肠病学和肝病学杂志, 2000, 9 (1) ∶42 [6]郑有为, 梁敏文, 王学健, 等酶联免疫吸附法检测庚型肝炎病毒抗体[J]中华实验和临床病毒学杂志, 2000, 14 (2) 151 [7] TanakaY , MizokamiMT , etal.NocorrelationbetweenGBV -C/HGVinfectionandhepatocellularcarcinoma[J]Hepatology, 1997, 26 (suppleB) ∶612-613. [8] JeffersIJ , PiatakM , BernsteinDE , etal.HepatitisGvirusinfec tioninpatientwithacuteandchronicliverdiseaseofunknownetiolo gy[J]〔Abstract〕Hepatology, 1995, 22∶182A . [9]貌盼勇, 洪世雯, 何红霞, 等合成肽抗原在庚型肝炎病毒抗体检测中的初步应用[J], 中华实验和临床病毒学杂志, 1996, 10 (3) 371 -
本文二维码
计量
- 文章访问数: 2295
- HTML全文浏览量: 17
- PDF下载量: 947
- 被引次数: 0
下载:
