PDF下载 ( 120 KB)
Expression of CD15 and Bcl-2 in gallbladder carcinoma and their relationship
-
摘要: 研究CD15抗原和bcl- 2癌基因蛋白产物在胆囊癌组织中的表达与组织类型、病理分级和转移的关系 ,并探讨CD15与癌基因蛋白表达的相关性。应用微波 -SP免疫组化法 ,检测 45例胆囊腺癌、17例胆囊腺瘤和10例慢性胆囊炎组织中CD15和bcl 2的表达水平。在胆囊癌中CD15和bcl 2阳性表达率分别为 71 1%和 6 0 %。其表达阳性率在胆囊癌中均明显高于胆囊腺瘤 （P <0 0 5 ） ,并与胆囊癌的组织类型、病理分级和转移密切相关 （P<0 0 5 ）。CD15表达与bcl 2表达呈明显相关联。CD15和bcl 2均是胆囊癌高度恶性和预后不良的重要生物学指标。胆囊癌CD15表达与bcl 2蛋白表达具有相互协同作用可能Abstract: WT5”BZ]To study the relationship of expression of CD15 antigen and bcl 2 oncogene with histological type, pathological grade and metastasis Microwave LSAB immunohistochemical technique was used to investigate the expression of CD15 and bcl 2 in 45 gallbladder carcinoma and 17 gallbladder adenoma and 10 chromic cholecystis The positive rate of CD15 and bcl 2 was 71 1% and 60 0%, which was positively correlated to the histologicaltypl, pathological grade and metastasis of carcinomas (P<0 05) and higber than that in gallbladder adenoma respeltively Expression of CD15 was significantly correlated with the expression of bcl 2 CD15 and bcl 2 might be important biologic markers to evaluate the malignancy and prognosis of gallbladder carcinoma There might be some extent coordinated regulation among them [WT5”HZ]
-
Key words:
- WT5”BZ]Gallbladder neoplasms /
- CD15 antigen /
- bcl 2 /
- immunohistochemistry
-
[1]陈金联 , 周同 选择素与肿瘤转移研究进展 [J] 生命科学 , 1996, 8 (1) ∶3 1 [][2 ]BrooksSA , LeathemAJC ExpressionoftheCD15antigen (LewisX) inbreastcancer HistochemJ[J] 1995 , 2 7 (9) ∶689 [][3 ]ToriiA , NakayamaA , HaradaA , etal ExpressionoftheCD15anti geninhepatocellularcarcinoma Cancer [J] 1993 , 71 (12 ) ∶3 864 [4]谷化平 , 尚培中 , 胡海霞 , 等 CD15和nM2 3 /NDPK在肾癌中的表达及其临床意义 [J] 中华泌尿外科杂志 , 1999, 2 0 (5 ) ∶3 10 [][5 ]KonetyBR , BullouB , JaffeR , etal ExpressionofSSEA 1 (LewisX) ontransitionalcellcarcinomaofthebladder [J] UrolInt , 1997, 5 8 (2 ) ∶69 [6]PezzellaF , TseAG , CordellJL , etal Expressionofthebcl 2onco geneproteinisnotspecificforthe 14∶18chromosomaltranslocation[J] AmJPathol, 1990 , 13 7∶2 2 5 [7]朱建伟 , 陈玉泉 , 薛化 , 等 甲状腺癌中原癌基因bcl 2的表达及意义 [J] 中华医学杂志 , 1996, 76 (1) ∶82 9 [8]李 鸣 , 于茂生 , 靳凤烁 , 等 联合应用C Haras , C myc反义寡聚脱氧核苷酸对膀胱癌细胞生长增殖的抑制作用 [J] , 中华外科杂志 , 1996, 3 4 (1) ∶7 [9]周 同 , 宋长玲 细胞粘附分子研究的某些进展 [J] 生命科学 , 1994, 6 (3 ) ∶2 7 -
本文二维码
计量
- 文章访问数: 3306
- HTML全文浏览量: 17
- PDF下载量: 794
- 被引次数: 0
下载:
