兰州地区TTV感染的血清学及临床研究

焦建中; 刘旺国; 李爱月; 焦建新; 邱瑛锋; 沈戌

兰州地区TTV感染的血清学及临床研究

解放军第一医院!(甘肃兰州730030)

详细信息

中图分类号: R446.1
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出版历程
- 出版日期: 2001-01-20

Clinical Study on Serology of TT Virus Infection and Pathogenicity in Lanzhou

摘要

摘要: 研究兰州地区供血员 ,静脉毒瘾者和肝病患者中TT病毒 (TTV)的感染状况及致病性。采用套式PCR技术检测 12 0例供血员 ,5 6例静脉毒瘾者和 74例肝病患者血清中TTVDNA。供血员TTVDNA检出率为7 5 % (9/12 0 ) ;静脉毒瘾者中TTVDNA检出率为 2 6 8% (15 /5 6 ) ;肝病患者中TTVDNA检出率为 13 4% (10 /74)。肝病患者的感染率与供血员和静脉毒瘾者相比 ,无显著性差异 (P >0 0 5 )。在 10例TTVDNA阳性患者 ,6例为单一TTV感染 ,4例ALT增高 ,3例呈急性肝炎的临床症状。TTV感染可经血液和胃肠道传播 ,多呈病毒携带状态 ,也可单独引起急性肝炎 ,但致病性较弱。对TTV的病原学、流行病学和临床意义还有待进一步研究。
- 输血传播病毒 /
- 套式多聚酶链反应 /
- 供血员 /
- 静脉毒瘾者 /
- 肝炎患者
Abstract: WT5”BZ]To study the infections rate and pathogenicity of transfusion transmitted Virus (TTV) among blood donors, intravenous drug abusers and patients with liver disease in Lanzhou TTV DNA from sera of blood donors intraverous drug abusers and patients with liver disease were detected by nested PCR (n PCR) :TTV DNA was detected in 9/120 (7 5%) sera of blood donors, in 15/56 (26 8%) sera of intravenous drug abusers and in 10/74 (13 4%) sera of patients with liver disease Among 10 TTV infected patients, there were 6 patients with Simple TTV infection, 4 cases were associated with elevated aminotransferase, 3 cases were AIH :The result indicated TTV that infection can be transmitted by blood and gastrointestinal but the pacthogenicity is mild Further study should be done to explore its eitiology epidmiology and clinical significance [WT5”HZ]
- WT5”BZ]Transfusion transmitted virus (TTV) /
- Nested PCR Blood Donor /
- Intraverous Drug abuser /
- Hepatitis /
- Pathogenicity

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参考文献(9)

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[][5 ]NishizawaT , OkamotoH , KonishiK , etal, AnovelDNA (TTV) as sociatedwithelevatedtransaminaselevelsinposttransfusionhepatitisofunknonetiology[J] BiochemBiophyResCommun , 1997, 2 41∶92

[6]刘旺国 , 聂青和 , 李爱月 , 等兰州地区献血员及静脉毒瘾者血清中TT病毒核酸检测及意义实用肝脏病杂志 , 1999, 4∶14 1

[7]病毒性肝炎防治方案 (试行 ) 中华传染病杂志 , 1995 , 13∶2 41

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[9] CossartY , TTV , acommonVirus, butpathogenic ?[J] Lancet, 1998, 3 5 2∶164

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