核酶:肝脏疾病基因治疗的新途径

徐峰; 陈智; 刘克洲

核酶:肝脏疾病基因治疗的新途径

浙江大学医学院附属一院传染病研究所!(浙江杭州310003)

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中图分类号: R456
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- 出版日期: 2001-01-20

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参考文献(15)

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[][2 ]SakamotoN , WuCH , WuGY IntracellularcleavageofhepatitisCvirusRNAandinhibitionofviralproteintranslationbyhammerheadribozymes[J] JClinInvest, 1996, 98∶2 72 0

[][3 ]BeckJ , NassalM Efficienthammerheadribozyme -mediatedcleav ageofthestructuredhepatitisBvirusencapsidationsignalinvitroandincellsextracts, butnotinintactcells[J] NucleicAcidsRes, 1995 , 2 3∶495 4

[4]WelchPJ, TritzR , YeiS , etal Intracellularapplicationofhairpinri bozymegenesaginsthepatitisBvirus[J] GeneTher , 1997, 4∶73 6

[][5 ]AltM , RenzR , HofschneiderPH , etal Specificinhibitionofhepati tisCvirus geneexpressionbyantisensephosphorothioateoligdeoxynucleotides[J] Hepatology , 1995 , 2 2∶70 7

[6] WakitaT , WandsJR SpecificinhibitionofhepatitisCexpressionbyantisenseoligodeoxynucleotides Invitromodelforselectinooftargetsequence[J] JBiolChem , 1994, 2 69∶14 2 0 5

[7]WelchPJ , TritzR , YeiS Apotentialtherapeuticapplicationofhair pinribozymes:invitroandinvivostudiesofgenetherapyforhepati tisCvirusinfection[J] GeneTher , 1996, 3∶994

[8]LieberA , HeCY , PolyakSJ, etal EliminationofhepatitisCvirusRNAininfectedhumanhepatocytesbyadenovirus-mediatedexpre sionofribozymes[J] JVirol, 1996, 70∶8782

[9]OhkawaK , YukiN , KanazawaY CleavageofviralRNAandinhibi tionofviraltranslationbyhepatitisCRNA -specifichammerheadribozymeinvitro[J] JHepatol, 1997, 2 7∶78

[][10 ]WelchPJ, YeiS , BarberJR RibozymegenetherapyforhepatitisCvirusinfection[J] ClinDiagnVirol, 1998, 10∶163

[11]RoyG , AnanvoranichS , PerraultJP Designofribozymestoselec tivelycleavethehumanhepatitisdeltavirusmRNA [J] NucleicAcidsSympSer, 1997, 3 6∶93

[][12 ]RoyG , AnanvoranichS , PerraultJP DeltaribozymehastheabilitytocleaveintransanmRNA[J] NucleicAcidsRes, 1999, 2 7∶942

[][13 ]ChenPJ, WuHL , WangCJ MolecularbiologyofhepatitisDvirus:researchandpotentialforapplication [J] JGastroenterolHeptol, 1997, 12∶188

[][14 ]KanazawaY , OhkawaK , UedaK Hammerheadribozyme-mediat edinhibitionoftelomeraseactivityinextractsofhumanhepatocellu larcarcinomacells[J] BiochemBiophysResCommun , 1996, 2 2 5∶5 70

[][15 ]GaughanDJ, SteelDM , WhiteheadAS Ribozymemediatedcleav ageofacutephaseserumA (A -SAA) mRNAinvitro[J] FEBSLett , 1997, 3 74∶2 41

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