PDF下载 ( 89 KB)
Prevalence of Anti-phospholipid Autoantibodi in patients with Chronic Hepatitis B Virus Infection
-
摘要: 探讨慢性乙肝病毒 (HBV)感染与抗磷脂抗体 (APA)水平的相关性 ;采用ELISA方法 ,检测慢性乙型肝炎及乙肝后肝硬化患者血清中APA的水平 ;与对照组相比 ,患者血清中APA均有显著升高 (P <0 0 5 ) ,且两组患者间亦有显著差异 (P <0 0 5 ) ;慢性HBV感染与APA相关且APA随病程的进展而升高Abstract: WT5”BZ]Antiphospholipid antibodies (APAs) have been reported in various clinical conditions The objective of the present study was to assess the prevalence of APAs in patients with chronic hepatitis B virus related liver diseases 32 healthy subject, 27 patients with chronic hepatitis B and 36 patients with liver cirrhosis after hepatitis B were assayed for serum APA level by ELISA Compared with healthy subjects, two groups of patients show increased APA positive rate (37% vs 3% and 36% vs 3% respectively, P<0 05) As for the APA levels both groups of patients manifested significant increased APA levels (0 3653±0 142 vs 0 2140±0 094 of hepatitis B group and 0 4430±0 127 vs 0 2140±0 094 of cirrhosis group <0 05) Thus, this study indicate APA is associated with chronic liver disease realted HBV infection [WT5”HZ]
-
[]〔1〕TriplettAD , Anti-phospolipidantibodies;laboratorydetectionandclini calrelevance ThrombosisandHaemostasis, 1995 , 74∶3 2 9 〔2〕ChedidA , ChadalawadeKR , MorganTR , etal PhospholipidantibodiesinalcoholicliverdiseaseHepatology , 1994, 2 0∶14 65 []〔3〕AbuafN , LunelF , GiralPetalNon -organspecificautoantibodiesasso ciatedwithchronicCvirushepatitis JournalofHepatology , 1993 , 18∶3 5 9 []〔4〕HariisEN , GharaviAE , HughesGKV Antiphospholipidantibodies ClinRheumDis , 1985 , 11∶5 91 〔5〕BironC , lalloyerN , TonnelotJL , etal Anticardiolipinantibodiesanda cutealcoholicintoxicationLupus, 1995 , 4∶486 〔6〕RosserBG , GoresGJ CellularmechanismsandclinicalimplicationsGas troenterology, 1995 , 10 8∶2 5 2 -
本文二维码
计量
- 文章访问数: 2321
- HTML全文浏览量: 14
- PDF下载量: 14
- 被引次数: 0
下载:
